DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: LIG_APCC_ABBA_1

Location: 468:473

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6291

ASA_SCORE: 97.35

COIL: 0.5778

CONS_SCORE: 0.3328

DSS_SCORE: 0.4371

HELIX: 0.2642

FCONS_SCORE: 1.0796

RIG_SCORE: 0.787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P474T	TCGA-2W-A8YY	CESC	TCGA	VKMFED	LIG_APCC_ABBA_1	0.3056
p.P474T	DO223732	CESC	ICGC	VKMFED	LIG_APCC_ABBA_1	0.3056
p.S476L	TCGA-4Z-AA7M	BLCA	TCGA	VKMFED	LIG_APCC_ABBA_1	0.25
p.S476L	DO218976	BLCA	ICGC	VKMFED	LIG_APCC_ABBA_1	0.25
p.P474H	TCGA-EO-A3KX	UCEC	TCGA	VKMFED	LIG_APCC_ABBA_1	0.3056
p.P474H	DO219774	UCEC	ICGC	VKMFED	LIG_APCC_ABBA_1	0.3056
p.D473V	TCGA-FR-A8YC	SKCM	TCGA	VKMFED	LIG_APCC_ABBA_1	0.7785
p.D473V	DO50301	SKCM	ICGC	VKMFED	LIG_APCC_ABBA_1	0.7785
p.M470I	DO233847	GACA	ICGC	VKMFED	LIG_APCC_ABBA_1	0.6507
p.P474S	DO220895	MELA	ICGC	VKMFED	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31629	Transcription factor HIVEP2	LIG_APCC_ABBA_1	468:473	VKMFED	APC,CDC20,FZR1	0.6291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons