DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: LIG_APCC_ABBA_1

Location: 2184:2189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7673

ASA_SCORE: 70.2167

COIL: 0.6752

CONS_SCORE: 0.3918

DSS_SCORE: 0.4016

HELIX: 0.0892

FCONS_SCORE: 0.841

RIG_SCORE: 0.7608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2182S	TCGA-98-A53J	LUSC	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.2778
p.P2182S	DO219183	LUSC	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.2778
p.G2192D	TCGA-A7-A3RF	BRCA	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.25
p.G2192D	TCGA-AZ-4614	COAD	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.25
p.G2192D	DO5583	BRCA	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.25
p.G2192D	DO10012	COAD	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.25
p.G2198D	TCGA-EK-A3GK	CESC	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.0833
p.G2198D	DO49964	CESC	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.0833
p.S2185G	TCGA-FI-A2D0	UCEC	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.5882
p.S2185G	DO43891	UCEC	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.5882
p.P2182L	TCGA-W3-AA1R	SKCM	TCGA	FSLYGD	LIG_APCC_ABBA_1	0.2778
p.P2182L	DO51275	SKCM	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.2778
p.Q2190K	DO229026	LICA	ICGC	FSLYGD	LIG_APCC_ABBA_1	0.3056
p.P2197Q	SIDM00845	Burkitt's Lymphoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1111
p.P2197Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1111
p.P2197Q	ACH-000786	Lymphoma	CCLE	FSLYGD	LIG_APCC_ABBA_1	0.1111
p.P2197Q	ACH-000992	Head and Neck Cancer	CCLE	FSLYGD	LIG_APCC_ABBA_1	0.1111
p.L2178I	SIDM00845	Burkitt's Lymphoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1667
p.L2178I	SIDM00461	Acute Myeloid Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1667
p.L2178I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1667
p.L2178I	SIDM01519	Head and Neck Carcinoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31629	Transcription factor HIVEP2	LIG_APCC_ABBA_1	2184:2189	FSLYGD	APC,CDC20,FZR1	0.7673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons