DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: LIG_APCC_ABBA_1

Location: 1189:1194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6351

ASA_SCORE: 84.0833

COIL: 0.7553

CONS_SCORE: 0.3497

DSS_SCORE: 0.5247

HELIX: 0.2143

FCONS_SCORE: 0.7424

RIG_SCORE: 0.7286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1195A	TCGA-78-7146	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.3056
p.T1195A	DO23717	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.3056
p.E1194Q	TCGA-86-6851	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.6744
p.E1194Q	TCGA-98-8021	LUSC	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.6744
p.E1194Q	DO23798	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.6744
p.E1194Q	DO27468	LUSC	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.6744
p.P1200L	TCGA-CV-7568	HNSC	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.1667
p.P1200L	DO14160	HNSC	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.1667
p.H1192Q	TCGA-EO-A22X	UCEC	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.7582
p.H1192Q	DO43907	UCEC	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.7582
p.Q1202R	TCGA-L9-A743	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.1111
p.Q1202R	DO49874	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.1111
p.Q1193E	TCGA-MA-AA3Y	CESC	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.5633
p.Q1193E	DO219721	CESC	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.5633
p.P1200S	TCGA-W3-AA1V	SKCM	TCGA	LFPHQE	LIG_APCC_ABBA_1	0.1667
p.P1200S	DO51276	SKCM	ICGC	LFPHQE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31629	Transcription factor HIVEP2	LIG_APCC_ABBA_1	1189:1194	LFPHQE	APC,CDC20,FZR1	0.6351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons