DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: DEG_APCC_DBOX_1

Location: 2078:2086

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8361

ASA_SCORE: 102.1222

COIL: 0.8692

CONS_SCORE: 0.5074

DSS_SCORE: 0.6865

HELIX: 0.1118

FCONS_SCORE: 0.8763

RIG_SCORE: 0.6105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2091K	TCGA-92-7340	LUSC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	0.1944
p.R2091K	DO26775	LUSC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.1944
p.L2088I	TCGA-AP-A1DV	UCEC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	0.2778
p.L2088I	DO43186	UCEC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.2778
p.S2089P	TCGA-B5-A3FA	UCEC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	0.25
p.S2089P	DO52402	UCEC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.25
p.G2068E	DO48391	BLCA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.0556
p.D2081N	DO227987	COCA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.5821
p.P2072L	DO222494	MELA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	0.1667
p.A2094T	ACH-001610	Brain Cancer	CCLE	PRRDLSPMR	DEG_APCC_DBOX_1	0.1111
p.L2096F	ACH-001864	Bile Duct Cancer	CCLE	PRRDLSPMR	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31629	Transcription factor HIVEP2	DEG_APCC_DBOX_1	2078:2086	PRRDLSPMR	APC,CDC20,FZR1	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons