DegronMD

Uniprot ID: Q8WWM7

Source protein: Ataxin-2-like protein

Source gene: ATXN2L

Class: DEG_SCF_FBW7_1

Location: 875:882

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 87.0125

COIL: 0.9698

CONS_SCORE: 0.3313

DSS_SCORE: 0.9041

HELIX: 0.0145

FCONS_SCORE: 1.0954

RIG_SCORE: 0.5255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A889V	TCGA-12-5299	GBM	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.A889V	TCGA-TM-A84J	LGG	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.A889V	DO13330	GBM	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.A889V	DO50236	LGG	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.A890P	TCGA-AJ-A3BG	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.1111
p.A890P	DO42633	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.1111
p.P884S	TCGA-AX-A0J1	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.2778
p.P884S	DO41199	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.2778
p.A865G	TCGA-BR-4292	STAD	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.0556
p.A865G	DO38495	STAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.0556
p.H871N	TCGA-CV-7238	HNSC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.2222
p.H871N	DO15246	HNSC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.2222
p.P879H	TCGA-FI-A2D5	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.7694
p.P879H	DO41331	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.7694
p.A889T	TCGA-HU-A4GT	STAD	TCGA	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.A889T	DO48020	STAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.1389
p.P884L	DO234389	ESAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.2778
p.T878M	DO233903	GACA	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.7423
p.A865S	DO229026	LICA	ICGC	PATTPTGS	DEG_SCF_FBW7_1	0.0556
p.S866F	ACH-000987	Skin Cancer	CCLE	PATTPTGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWM7	Ataxin-2-like protein	DEG_SCF_FBW7_1	875:882	PATTPTGS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons