DegronMD

Uniprot ID: Q5CZC0

Source protein: Fibrous sheath-interacting protein 2

Source gene: FSIP2

Class: DEG_APCC_KENBOX_2

Location: 5434:5438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8312

ASA_SCORE: 99.82

COIL: 0.6098

CONS_SCORE: 0.5735

DSS_SCORE: 0.4339

HELIX: 0.274

FCONS_SCORE: 1.2215

RIG_SCORE: 0.736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E5446G	TCGA-AX-A1CE	UCEC	TCGA	AKENQ	DEG_APCC_KENBOX_2	0.1111
p.E5446G	DO42280	UCEC	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.1111
p.D5438N	TCGA-CN-6013	HNSC	TCGA	AKENQ	DEG_APCC_KENBOX_2	0.6932
p.S5441F	TCGA-CN-6013	HNSC	TCGA	AKENQ	DEG_APCC_KENBOX_2	0.25
p.S5441F	DO15975	HNSC	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.25
p.E5436K	DO219006	BLCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.7022
p.L5439I	DO225325	BRCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.3056
p.S5428A	DO48211	ESCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.1667
p.D5448N	DO220876	MELA	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.0556
p.D5448N	DO222363	MELA	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.0556
p.E5436D	DO41379	UCEC	ICGC	AKENQ	DEG_APCC_KENBOX_2	0.6758
p.D5443Y	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AKENQ	DEG_APCC_KENBOX_2	0.1944
p.D5443Y	ACH-000888	Lung Cancer	CCLE	AKENQ	DEG_APCC_KENBOX_2	0.1944
p.D5443Y	NCI-H1793	lung	COSMIC	AKENQ	DEG_APCC_KENBOX_2	0.1944
p.S5440Y	SIDM01588	Endometrial Carcinoma	GDSC	AKENQ	DEG_APCC_KENBOX_2	0.2778
p.S5440Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	AKENQ	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_APCC_KENBOX_2	5434:5438	AKENQ	APC,CDC20,FZR1	0.8312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons