DegronMD

Uniprot ID: Q9NYQ8

Source protein: Protocadherin Fat 2

Source gene: FAT2

Class: DEG_Kelch_Keap1_1

Location: 2325:2330

E3 ligase: KEAP1

DEGRON score: 0.6259

ASA_SCORE: 49.15

COIL: 0.6267

CONS_SCORE: 0.6662

DSS_SCORE: 0.3931

HELIX: 0.0203

FCONS_SCORE: 1.1785

RIG_SCORE: 0.6808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2338N	TCGA-AX-A0J1	UCEC	TCGA	NGSTGE	DEG_Kelch_Keap1_1	0.1111
p.D2338N	DO41199	UCEC	ICGC	NGSTGE	DEG_Kelch_Keap1_1	0.1111
p.S2316P	TCGA-AX-A2HJ	UCEC	TCGA	NGSTGE	DEG_Kelch_Keap1_1	0.0833
p.S2316P	DO42105	UCEC	ICGC	NGSTGE	DEG_Kelch_Keap1_1	0.0833
p.E2340V	TCGA-CM-5868	COAD	TCGA	NGSTGE	DEG_Kelch_Keap1_1	0.0556
p.E2340V	DO7894	COAD	ICGC	NGSTGE	DEG_Kelch_Keap1_1	0.0556
p.S2332P	TCGA-F5-6814	READ	TCGA	NGSTGE	DEG_Kelch_Keap1_1	0.2778
p.S2332P	DO36556	READ	ICGC	NGSTGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ8	Protocadherin Fat 2	DEG_Kelch_Keap1_1	2325:2330	NGSTGE	KEAP1	0.6259	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons