DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 78.08

COIL: 0.8952

CONS_SCORE: 0.3522

DSS_SCORE: 0.5517

HELIX: 0.0728

FCONS_SCORE: 0.9778

RIG_SCORE: 0.6185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S493R	TCGA-18-3421	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.5
p.A517E	TCGA-34-2604	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.0556
p.P496L	TCGA-3N-A9WD	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.L500F	TCGA-44-4112	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.25
p.S516I	TCGA-55-6968	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.0833
p.A503D	TCGA-64-5778	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.7793
p.I497T	TCGA-69-7978	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.1667
p.I497T	TCGA-BT-A42C	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	0.1667
p.A501G	TCGA-69-7978	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.2778
p.T506P	TCGA-75-7031	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.7031
p.T506N	TCGA-98-8021	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.7055
p.S505N	TCGA-B5-A11E	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	0.7069
p.T512A	TCGA-B5-A3FA	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	0.1944
p.E504K	TCGA-BA-5152	HNSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.591
p.E504K	TCGA-VQ-A92D	STAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.591
p.S514F	TCGA-ER-A19F	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.S514F	TCGA-FW-A3R5	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.P495T	TCGA-EW-A1J5	BRCA	TCGA	AESTS	DEG_SPOP_SBC_1	0.1111
p.S510L	TCGA-FI-A2D5	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	0.25
p.A503G	TCGA-MP-A4TK	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.754
p.R502W	TCGA-OR-A5LJ	ACC	TCGA	AESTS	DEG_SPOP_SBC_1	0.3056
p.P515H	DO218136	GACA	ICGC	AESTS	DEG_SPOP_SBC_1	0.1111
p.R514I	DO14173	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.1389
p.R495W	DO27310	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.1111
p.R495W	DO41871	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	0.1111
p.R495L	DO27310	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.1111
p.G510R	DO47234	RECA	ICGC	AESTS	DEG_SPOP_SBC_1	0.25
p.S498F	DO37819	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	0.1944
p.P497Q	DO38443	STAD	ICGC	AESTS	DEG_SPOP_SBC_1	0.1667
p.A501V	SIDM00216	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.2778
p.A501V	ACH-000989	Colon/Colorectal Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	0.2778
p.A501V	SNU-175	large_intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	0.2778
p.S517N	Mewo	skin	COSMIC	AESTS	DEG_SPOP_SBC_1	0.0556
p.P494S	HT-3	cervix	COSMIC	AESTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	300:304	AESTS	SPOP	0.7654	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	503:507	AESTS	SPOP	0.9972	More...
Q9H3U7	SPARC-related modular calcium-binding protein 2	DEG_SPOP_SBC_1	434:438	AESTS	SPOP	0.8688	More...
Q9UPQ0	LIM and calponin homology domains-containing protein 1	DEG_SPOP_SBC_1	323:327	AESTS	SPOP	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESTS

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of AESTS