DegronMD - Q9H3U7(SMOC2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D430E	TCGA-18-3406	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.D430E	DO26438	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.G425S	TCGA-19-5956	GBM	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation substituting flanking lysine	0.1944
p.G425S	DO13863	GBM	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation substituting flanking lysine	0.1944
p.T435A	TCGA-A5-A1OF	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7139
p.G431S	TCGA-AA-3672	COAD	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.A433T	TCGA-AP-A1DV	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.A433T	DO43186	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.D434N	TCGA-BR-6452	STAD	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.6932
p.A445T	TCGA-C4-A0F1	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.A445T	DO581	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.R442I	TCGA-D3-A3C8	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R442I	DO47636	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.A427T	TCGA-DU-A7TC	LGG	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.G431V	TCGA-ER-A2NB	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.G431V	DO47448	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.R442K	TCGA-FJ-A3ZF	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R442K	DO500	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R442T	TCGA-L9-A7SV	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R442T	DO49875	LUAD	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R427C	DO222448	ESCA	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.G432D	DO233944	GACA	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2778
p.S438F	DO14662	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7982
p.T437M	DO232761	PBCA	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7423
p.T424A	DO42568	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.0556
p.T440N	SIDM01944	Esophageal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2778
p.A433V	SIDM00855	Other Sarcomas	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.A433V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.A433V	SIDM01173	Rhabdomyosarcoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.G431D	SIDM00537	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.G431D	GP5d	large intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.P441A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.P441A	NCI-H2342	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.A427V	SIDM00217	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.A427V	SNU-1040	large intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.P430A	ACH-000951	Lung Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.P430A	NCI-H2342	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.Q445L	ACH-001203	Lymphoma	CCLE	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.Q445L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	AESTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389

Kaplan plot for SMOC2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMOC2

UniProt ID: Q9H3U7

Entrez ID: 64094

Protein name: SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SMOC2 in