DegronMD

Uniprot ID: Q9H3U7

Source protein: SPARC-related modular calcium-binding protein 2

Source gene: SMOC2

Class: DEG_SPOP_SBC_1

Location: 434:438

E3 ligase: SPOP

DEGRON score: 0.8688

ASA_SCORE: 98

COIL: 0.9286

CONS_SCORE: 0.2816

DSS_SCORE: 0.8987

HELIX: 0.0508

FCONS_SCORE: 0.9513

RIG_SCORE: 0.5935

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D430E	TCGA-18-3406	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.2222
p.D430E	DO26438	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.G425S	TCGA-19-5956	GBM	TCGA	AESTS	DEG_SPOP_SBC_1	0.1944
p.G425S	DO13863	GBM	ICGC	AESTS	DEG_SPOP_SBC_1	0.1944
p.T435A	TCGA-A5-A1OF	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	0.7139
p.G431S	TCGA-AA-3672	COAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.25
p.A433T	TCGA-AP-A1DV	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	0.3056
p.A433T	DO43186	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	0.3056
p.D434N	TCGA-BR-6452	STAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.6932
p.A445T	TCGA-C4-A0F1	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.A445T	DO581	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	0.1389
p.R442I	TCGA-D3-A3C8	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.2222
p.R442I	DO47636	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.A427T	TCGA-DU-A7TC	LGG	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.G431V	TCGA-ER-A2NB	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.25
p.G431V	DO47448	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	0.25
p.R442K	TCGA-FJ-A3ZF	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	0.2222
p.R442K	DO500	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.R442T	TCGA-L9-A7SV	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	0.2222
p.R442T	DO49875	LUAD	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.R427C	DO222448	ESCA	ICGC	AESTS	DEG_SPOP_SBC_1	0.1389
p.G432D	DO233944	GACA	ICGC	AESTS	DEG_SPOP_SBC_1	0.2778
p.S438F	DO14662	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.7982
p.T437M	DO232761	PBCA	ICGC	AESTS	DEG_SPOP_SBC_1	0.7423
p.T424A	DO42568	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	0.0556
p.T440N	SIDM01944	Esophageal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.2778
p.A433V	SIDM00855	Other Sarcomas	GDSC	AESTS	DEG_SPOP_SBC_1	0.3056
p.A433V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.3056
p.A433V	SIDM01173	Rhabdomyosarcoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.3056
p.G431D	SIDM00537	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.25
p.G431D	GP5d	large_intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	0.25
p.P441A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.25
p.P441A	NCI-H2342	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	0.25
p.A427V	SIDM00217	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.1389
p.A427V	SNU-1040	large_intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1389
p.P430A	ACH-000951	Lung Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	0.2222
p.P430A	NCI-H2342	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	0.2222
p.Q445L	ACH-001203	Lymphoma	CCLE	AESTS	DEG_SPOP_SBC_1	0.1389
p.Q445L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	300:304	AESTS	SPOP	0.7654	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	503:507	AESTS	SPOP	0.9972	More...
Q9H3U7	SPARC-related modular calcium-binding protein 2	DEG_SPOP_SBC_1	434:438	AESTS	SPOP	0.8688	More...
Q9UPQ0	LIM and calponin homology domains-containing protein 1	DEG_SPOP_SBC_1	323:327	AESTS	SPOP	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESTS

Degron related mutations and impact score

Drug responses associated with SMOC2 mutations

All proteins holding degron of AESTS