DegronMD

Uniprot ID: Q96AG3

Source protein: Mitochondrial outer membrane protein SLC25A46

Source gene: SLC25A46

Class: DEG_SPOP_SBC_1

Location: 300:304

E3 ligase: SPOP

DEGRON score: 0.7654

ASA_SCORE: 83.5

COIL: 0.844

CONS_SCORE: 0.4244

DSS_SCORE: 0.1557

HELIX: 0.1268

FCONS_SCORE: 1.2276

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F314L	TCGA-CQ-5334	HNSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.0556
p.M309V	TCGA-EE-A3JB	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.1944
p.T303I	TCGA-FR-A8YC	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	0.7078
p.A300T	SIDM01201	Other Blood Cancers	GDSC	AESTS	DEG_SPOP_SBC_1	0.7139
p.A300T	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	AESTS	DEG_SPOP_SBC_1	0.7139
p.Y295S	SIDM00279	Gastric Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	0.1944
p.Y295S	ECC12	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1944
p.A310V	OC-314	ovary	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	300:304	AESTS	SPOP	0.7654	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	503:507	AESTS	SPOP	0.9972	More...
Q9H3U7	SPARC-related modular calcium-binding protein 2	DEG_SPOP_SBC_1	434:438	AESTS	SPOP	0.8688	More...
Q9UPQ0	LIM and calponin homology domains-containing protein 1	DEG_SPOP_SBC_1	323:327	AESTS	SPOP	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons