DegronMD - Q9UPQ0(LIMCH1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R316S	TCGA-37-4135	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.A323T	TCGA-51-6867	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7139
p.P831Q	TCGA-B5-A1MX	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.25
p.S847C	TCGA-BH-A2L8	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.M848V	TCGA-BR-8487	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0556
p.P831S	TCGA-EE-A3AF	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.25
p.S320C	TCGA-XF-AAN3	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	323:327	Mutation blocking phosphorylation signal	0.6944
p.P329L	DO48424	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778
p.R324W	DO223732	CESC	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.8634
p.R324W	DO35242	PACA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.8634
p.N318K	DO7798	COAD	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.A832T	DO10880	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.P317S	DO15206	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation blocking phosphorylation signal	0.6111
p.C846F	DO229026	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.G325S	DO25320	LUAD	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6993
p.G332R	DO220901	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.E836K	DO220903	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7022
p.G319E	DO220902	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2222
p.Y315H	DO222359	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.D324N	DO222731	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6932
p.H843Y	DO222810	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1944
p.P319H	DO51494	PACA	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2222
p.Y841N	DO37699	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.25
p.P826L	DO37419	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.P826L	DO50286	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.P826L	Sarc9371	bone	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.L840F	DO38099	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.M320I	DO51252	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation blocking phosphorylation signal	0.6944
p.M320I	DO42568	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation blocking phosphorylation signal	0.6944
p.I844T	DO38619	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.I844N	DO47912	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.R324Q	DO42985	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7329
p.R844C	SIDM00392	Melanoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.R844C	SIDM00120	Prostate Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.R844C	SIDM00195	Ewing's Sarcoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.R844C	SIDM01777	Pancreatic Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.G826E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.G826E	NCI-H1573	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.M327I	ACH-000523	Lung Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7618
p.K825M	ACH-000627	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.K825M	LCLC-103H	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.L330M	ACH-000932	Gastric Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.L330M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.A839V	ACH-000962	Ovarian Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.3056
p.A839V	ACH-001145	Ovarian Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.3056
p.A839V	OC-314	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.3056
p.S847F	Hs939-T	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.T827P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1389
p.A832V	OC-314	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.K830M	LCLC-103H	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2222
p.K838M	LCLC-103H	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.8062
p.A330G	RERF-GC-1B	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.L318M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.I834V	MFE-319	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7076
p.A335T	NY	bone	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.A335G	RERF-GC-1B	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.T828P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.I826V	MFE-319	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.P832L	LNCaP-Clone-FGC	prostate	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.L323M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.711
p.H316Y	NCI-H2172	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.A839S	IGROV-1	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.3056
p.L335M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.T840P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.S846F	Hs939-T	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1111
p.A330T	NY	bone	COSMIC	AESTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.A844V	OC-314	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.I840V	MFE-319	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.K844M	LCLC-103H	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.1667
p.G833S	LoVo	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.3056
p.A838S	IGROV-1	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7588
p.R834H	COLO-800	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIMCH1

UniProt ID: Q9UPQ0

Entrez ID: 22998

Protein name: LIM and calponin homology domains-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LIMCH1 in