DegronMD

Uniprot ID: Q9UPQ0

Source protein: LIM and calponin homology domains-containing protein 1

Source gene: LIMCH1

Class: DEG_SPOP_SBC_1

Location: 323:327

E3 ligase: SPOP

DEGRON score: 0.9794

ASA_SCORE: 73.96

COIL: 0.6816

CONS_SCORE: 0.3857

DSS_SCORE: 0.5874

HELIX: 0.237

FCONS_SCORE: 1.1141

RIG_SCORE: 0.6777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R316S	TCGA-37-4135	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.1389
p.A323T	TCGA-51-6867	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	0.7139
p.S320C	TCGA-XF-AAN3	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	0.6944
p.P329L	DO48424	BLCA	ICGC	AESTS	DEG_SPOP_SBC_1	0.2778
p.R324W	DO223732	CESC	ICGC	AESTS	DEG_SPOP_SBC_1	0.8634
p.R324W	DO35242	PACA	ICGC	AESTS	DEG_SPOP_SBC_1	0.8634
p.N318K	DO7798	COAD	ICGC	AESTS	DEG_SPOP_SBC_1	0.1944
p.P317S	DO15206	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	0.6111
p.G325S	DO25320	LUAD	ICGC	AESTS	DEG_SPOP_SBC_1	0.6993
p.G332R	DO220901	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	0.1944
p.G319E	DO220902	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.Y315H	DO222359	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	0.1111
p.D324N	DO222731	MELA	ICGC	AESTS	DEG_SPOP_SBC_1	0.6932
p.P319H	DO51494	PACA	ICGC	AESTS	DEG_SPOP_SBC_1	0.2222
p.M320I	DO51252	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	0.6944
p.M320I	DO42568	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	0.6944
p.R324Q	DO42985	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	0.7329
p.M327I	ACH-000523	Lung Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	0.7618
p.L330M	ACH-000932	Gastric Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	0.25
p.L330M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.25
p.A330G	RERF-GC-1B	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.25
p.L318M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1944
p.A335T	NY	bone	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1111
p.A335G	RERF-GC-1B	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1111
p.L323M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.711
p.H316Y	NCI-H2172	lung	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1389
p.L335M	NCI-SNU-1	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	0.1111
p.A330T	NY	bone	COSMIC	AESTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	300:304	AESTS	SPOP	0.7654	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	503:507	AESTS	SPOP	0.9972	More...
Q9H3U7	SPARC-related modular calcium-binding protein 2	DEG_SPOP_SBC_1	434:438	AESTS	SPOP	0.8688	More...
Q9UPQ0	LIM and calponin homology domains-containing protein 1	DEG_SPOP_SBC_1	323:327	AESTS	SPOP	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons