DegronMD - Q96AG3(SLC25A46)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F314L	TCGA-CQ-5334	HNSC	TCGA	AESTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.0556
p.M309V	TCGA-EE-A3JB	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.T303I	TCGA-FR-A8YC	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7078
p.H56Y	DO233748	GACA	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.A73T	DO22237	LGG	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.V65L	DO229028	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.Y64C	DO230929	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation blocking phosphorylation signal	0.7222
p.Y64C	DO224572	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation blocking phosphorylation signal	0.7222
p.S72L	DO52363	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P67R	DO227531	PACA	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.6401
p.L75Q	DO37951	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.A67P	DO42023	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7503
p.A73S	DO52402	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.A300T	SIDM01201	Other Blood Cancers	GDSC	AESTS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7139
p.A300T	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	AESTS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7139
p.P76A	SIDM00239	Kidney Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.P76A	ACH-000159	Kidney Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.G75S	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.G75S	ACH-000727	Lung Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.Y295S	SIDM00279	Gastric Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.Y295S	ECC12	stomach	COSMIC	AESTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.W57G	ACH-000997	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.W57G	ACH-001061	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.V79L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.V63L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.A310V	OC-314	ovary	COSMIC	AESTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667

Kaplan plot for SLC25A46 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC25A46

UniProt ID: Q96AG3

Entrez ID: 91137

Protein name: Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLC25A46 in