DegronMD

Uniprot ID: Q96AG3

Source protein: Mitochondrial outer membrane protein SLC25A46

Source gene: SLC25A46

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 86.26

COIL: 0.9586

CONS_SCORE: 0.3357

DSS_SCORE: 0.6897

HELIX: 0.0106

FCONS_SCORE: 1.1401

RIG_SCORE: 0.6299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H56Y	DO233748	GACA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.A73T	DO22237	LGG	ICGC	VPTTS	DEG_SPOP_SBC_1	0.25
p.V65L	DO229028	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.3056
p.Y64C	DO230929	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.7222
p.Y64C	DO224572	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.7222
p.S72L	DO52363	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.2778
p.P67R	DO227531	PACA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.6401
p.L75Q	DO37951	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.A67P	DO42023	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.7503
p.A73S	DO52402	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.25
p.P76A	SIDM00239	Kidney Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.P76A	ACH-000159	Kidney Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.1667
p.G75S	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.G75S	ACH-000727	Lung Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.1944
p.W57G	ACH-000997	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.0833
p.W57G	ACH-001061	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.0833
p.V79L	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	0.0833
p.V63L	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	370:374	VPTTS	SPOP	0.8558	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2399:2403	VPTTS	SPOP	0.8982	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2495:2499	VPTTS	SPOP	0.7928	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2575:2579	VPTTS	SPOP	0.5198	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2671:2675	VPTTS	SPOP	0.9448	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2839:2843	VPTTS	SPOP	0.9083	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2935:2939	VPTTS	SPOP	0.9476	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2951:2955	VPTTS	SPOP	0.798	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2959:2963	VPTTS	SPOP	0.6777	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3071:3075	VPTTS	SPOP	0.6444	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3159:3163	VPTTS	SPOP	0.5848	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3191:3195	VPTTS	SPOP	0.7503	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3922:3926	VPTTS	SPOP	0.7805	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4228:4232	VPTTS	SPOP	0.9669	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4300:4304	VPTTS	SPOP	0.9127	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4324:4328	VPTTS	SPOP	0.7065	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4444:4448	VPTTS	SPOP	0.8216	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4516:4520	VPTTS	SPOP	0.9642	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4596:4600	VPTTS	SPOP	0.5935	More...
Q05707	Collagen alpha-1	DEG_SPOP_SBC_1	725:729	VPTTS	SPOP	0.9814	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	1284:1288	VPTTS	SPOP	0.9896	More...
Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	DEG_SPOP_SBC_1	381:385	VPTTS	SPOP	0.942	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	395:399	VPTTS	SPOP	0.9894	More...
Q8N5I2	Arrestin domain-containing protein 1	DEG_SPOP_SBC_1	393:397	VPTTS	SPOP	0.995	More...
Q8TDF5	Neuropilin and tolloid-like protein 1	DEG_SPOP_SBC_1	498:502	VPTTS	SPOP	0.9808	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13290:13294	VPTTS	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13602:13606	VPTTS	SPOP	0.9442	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13913:13917	VPTTS	SPOP	0.8716	More...
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	66:70	VPTTS	SPOP	0.9982	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	3459:3463	VPTTS	SPOP	0.9438	More...
Q9HBW1	Leucine-rich repeat-containing protein 4	DEG_SPOP_SBC_1	476:480	VPTTS	SPOP	0.9425	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	158:162	VPTTS	SPOP	0.9979	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1828:1832	VPTTS	SPOP	0.5647	More...
Q9NU02	Ankyrin repeat and EF-hand domain-containing protein 1	DEG_SPOP_SBC_1	687:691	VPTTS	SPOP	0.9845	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_SPOP_SBC_1	257:261	VPTTS	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTS

Degron related mutations and impact score

Drug responses associated with SLC25A46 mutations

All proteins holding degron of VPTTS