DegronMD - Q6PFW1(PPIP5K1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1374V	TCGA-44-3398	LUAD	TCGA	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1667
p.E1374V	DO25030	LUAD	ICGC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1667
p.E1374Q	TCGA-44-3398	LUAD	TCGA	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1667
p.E1374Q	DO25030	LUAD	ICGC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1667
p.F1386L	TCGA-D1-A103	UCEC	TCGA	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.3056
p.F1386L	DO42312	UCEC	ICGC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.3056
p.R1160C	TCGA-EI-6507	READ	TCGA	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.2222
p.R1160C	DO36675	READ	ICGC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.2222
p.S1168N	TCGA-EO-A22U	UCEC	TCGA	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.3056
p.S1168N	DO43755	UCEC	ICGC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.3056
p.P1376L	TCGA-FW-A3R5	SKCM	TCGA	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.2222
p.P1376L	DO37406	SKCM	ICGC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.2222
p.S1161Y	TCGA-GU-AATP	BLCA	TCGA	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.25
p.S1161Y	DO51894	BLCA	ICGC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.25
p.L1155M	DO229026	LICA	ICGC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.0833
p.R1160H	DO23340	LINC	ICGC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.2222
p.E1162Q	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.2778
p.E1162Q	NCI-H650	lung	COSMIC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.2778
p.R392C	ACH-000845	Lung Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.P1165T	ACH-000985	Colon/Colorectal Cancer	CCLE	PPWY	ITCH	1164:1167	Mutation altering degron motif	0.7031
p.F1390L	ACH-002102	Lung Cancer	CCLE	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1944
p.F1390L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1944
p.E1158Q	NCI-H650	lung	COSMIC	PPWY	ITCH	1164:1167	Mutation rewiring degron network	0.1667
p.F1393L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1111
p.F1392L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	1380:1385	Mutation rewiring degron network	0.1389

Kaplan plot for PPIP5K1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIP5K1

UniProt ID: Q6PFW1

Entrez ID: 9677

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPIP5K1 in