DegronMD

Uniprot ID: Q6PFW1

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Source gene: PPIP5K1

Class: LIG_APCC_ABBA_1

Location: 1380:1385

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.781

ASA_SCORE: 108.8333

COIL: 0.826

CONS_SCORE: 0.294

DSS_SCORE: 0.3297

HELIX: 0.1348

FCONS_SCORE: 0.9665

RIG_SCORE: 0.8348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1374V	TCGA-44-3398	LUAD	TCGA	IQPYQE	LIG_APCC_ABBA_1	0.1667
p.E1374V	DO25030	LUAD	ICGC	IQPYQE	LIG_APCC_ABBA_1	0.1667
p.E1374Q	TCGA-44-3398	LUAD	TCGA	IQPYQE	LIG_APCC_ABBA_1	0.1667
p.E1374Q	DO25030	LUAD	ICGC	IQPYQE	LIG_APCC_ABBA_1	0.1667
p.F1386L	TCGA-D1-A103	UCEC	TCGA	IQPYQE	LIG_APCC_ABBA_1	0.3056
p.F1386L	DO42312	UCEC	ICGC	IQPYQE	LIG_APCC_ABBA_1	0.3056
p.P1376L	TCGA-FW-A3R5	SKCM	TCGA	IQPYQE	LIG_APCC_ABBA_1	0.2222
p.P1376L	DO37406	SKCM	ICGC	IQPYQE	LIG_APCC_ABBA_1	0.2222
p.F1390L	ACH-002102	Lung Cancer	CCLE	IQPYQE	LIG_APCC_ABBA_1	0.1944
p.F1390L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	0.1944
p.F1393L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	0.1111
p.F1392L	EMC-BAC-2	lung	COSMIC	IQPYQE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	LIG_APCC_ABBA_1	1380:1385	IQPYQE	APC,CDC20,FZR1	0.781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons