DegronMD

Uniprot ID: Q6PFW1

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Source gene: PPIP5K1

Class: ITCH

Location: 1164:1167

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8451

ASA_SCORE: 98.95

COIL: 0.9383

CONS_SCORE: 0.3059

DSS_SCORE: 0.6945

HELIX: 0.0298

FCONS_SCORE: 1.0432

RIG_SCORE: 0.6024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1160C	TCGA-EI-6507	READ	TCGA	PPWY	ITCH	0.2222
p.R1160C	DO36675	READ	ICGC	PPWY	ITCH	0.2222
p.S1168N	TCGA-EO-A22U	UCEC	TCGA	PPWY	ITCH	0.3056
p.S1168N	DO43755	UCEC	ICGC	PPWY	ITCH	0.3056
p.S1161Y	TCGA-GU-AATP	BLCA	TCGA	PPWY	ITCH	0.25
p.S1161Y	DO51894	BLCA	ICGC	PPWY	ITCH	0.25
p.L1155M	DO229026	LICA	ICGC	PPWY	ITCH	0.0833
p.R1160H	DO23340	LINC	ICGC	PPWY	ITCH	0.2222
p.E1162Q	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPWY	ITCH	0.2778
p.E1162Q	NCI-H650	lung	COSMIC	PPWY	ITCH	0.2778
p.P1165T	ACH-000985	Colon/Colorectal Cancer	CCLE	PPWY	ITCH	0.7031
p.E1158Q	NCI-H650	lung	COSMIC	PPWY	ITCH	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	ITCH	1164:1167	PPWY	ITCH,NEDD4	0.8451	More...
Q96BZ8	Leukocyte receptor cluster member 1	ITCH	128:131	PPWY	ITCH,NEDD4	0.9953	More...
Q9GZV8	PR domain zinc finger protein 14	ITCH	99:102	PPWY	ITCH,NEDD4	0.5809	More...
Q9NWZ5	Uridine-cytidine kinase-like 1	ITCH	85:88	PPWY	ITCH,NEDD4	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons