DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPWY
Uniprot ID:
Q96BZ8
Source protein:
Leukocyte receptor cluster member 1
Source gene:
LENG1
Class:
ITCH
Location:
128:131
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9953
ASA_SCORE:
60.975
COIL:
0.817
CONS_SCORE:
0.7941
DSS_SCORE:
0.7414
HELIX:
0.1273
FCONS_SCORE:
1.2892
RIG_SCORE:
0.694
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G118D
TCGA-UY-A9PF
BLCA
TCGA
PPWY
ITCH
0.0556
p.G118D
DO219044
BLCA
ICGC
PPWY
ITCH
0.0556
Drug responses associated with LENG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPWY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6PFW1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
ITCH
1164:1167
PPWY
ITCH,NEDD4
0.8451
More...
Q96BZ8
Leukocyte receptor cluster member 1
ITCH
128:131
PPWY
ITCH,NEDD4
0.9953
More...
Q9GZV8
PR domain zinc finger protein 14
ITCH
99:102
PPWY
ITCH,NEDD4
0.5809
More...
Q9NWZ5
Uridine-cytidine kinase-like 1
ITCH
85:88
PPWY
ITCH,NEDD4
0.9964
More...
