DegronMD - Q96BZ8(LENG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G88V	TCGA-98-A53I	LUSC	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.1389
p.G88V	DO219182	LUSC	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.1389
p.G74D	TCGA-AB-2806	LAML	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.2778
p.G74D	DO21283	LAML	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.2778
p.E67K	TCGA-AC-A6IV	BRCA	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.0833
p.E67K	DO44246	BRCA	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.0833
p.R80W	TCGA-C5-A8XH	CESC	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation altering degron motif	0.7523
p.R80W	DO49898	CESC	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation altering degron motif	0.7523
p.A66T	TCGA-F1-6177	STAD	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.0556
p.A66T	DO38727	STAD	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.0556
p.G118D	TCGA-UY-A9PF	BLCA	TCGA	PPWY	ITCH	128:131	Mutation rewiring degron network	0.0556
p.G118D	DO219044	BLCA	ICGC	PPWY	ITCH	128:131	Mutation rewiring degron network	0.0556
p.G86R	TCGA-YF-AA3M	BLCA	TCGA	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.1944
p.G86R	DO51952	BLCA	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.1944
p.P75H	DO233764	GACA	ICGC	VDLFRE	LIG_APCC_ABBA_1	76:81	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons