DegronMD

Uniprot ID: Q96BZ8

Source protein: Leukocyte receptor cluster member 1

Source gene: LENG1

Class: LIG_APCC_ABBA_1

Location: 76:81

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9173

ASA_SCORE: 72.6833

COIL: 0.4303

CONS_SCORE: 0.6482

DSS_SCORE: 0.5123

HELIX: 0.5253

FCONS_SCORE: 1.2569

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G88V	TCGA-98-A53I	LUSC	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.1389
p.G88V	DO219182	LUSC	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.1389
p.G74D	TCGA-AB-2806	LAML	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.2778
p.G74D	DO21283	LAML	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.2778
p.E67K	TCGA-AC-A6IV	BRCA	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.0833
p.E67K	DO44246	BRCA	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.0833
p.R80W	TCGA-C5-A8XH	CESC	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.7523
p.R80W	DO49898	CESC	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.7523
p.A66T	TCGA-F1-6177	STAD	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.0556
p.A66T	DO38727	STAD	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.0556
p.G86R	TCGA-YF-AA3M	BLCA	TCGA	VDLFRE	LIG_APCC_ABBA_1	0.1944
p.G86R	DO51952	BLCA	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.1944
p.P75H	DO233764	GACA	ICGC	VDLFRE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BZ8	Leukocyte receptor cluster member 1	LIG_APCC_ABBA_1	76:81	VDLFRE	APC,CDC20,FZR1	0.9173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons