DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPWY
Uniprot ID:
Q9NWZ5
Source protein:
Uridine-cytidine kinase-like 1
Source gene:
UCKL1
Class:
ITCH
Location:
85:88
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9964
ASA_SCORE:
44
COIL:
0.734
CONS_SCORE:
0.3866
DSS_SCORE:
0.5721
HELIX:
0.0572
FCONS_SCORE:
1.2221
RIG_SCORE:
0.7219
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R77H
TCGA-AX-A1CE
UCEC
TCGA
PPWY
ITCH
0.1111
p.R77H
TCGA-DF-A2KU
UCEC
TCGA
PPWY
ITCH
0.1111
p.Y88H
TCGA-BG-A222
UCEC
TCGA
PPWY
ITCH
0.7229
p.I79M
TCGA-BR-8690
STAD
TCGA
PPWY
ITCH
0.1667
p.I79M
TCGA-IN-A6RL
STAD
TCGA
PPWY
ITCH
0.1667
p.I79M
DO51738
STAD
ICGC
PPWY
ITCH
0.1667
p.I79M
DO47911
STAD
ICGC
PPWY
ITCH
0.1667
p.R84Q
TCGA-DU-5847
LGG
TCGA
PPWY
ITCH
0.3056
p.G92S
TCGA-IQ-A61E
HNSC
TCGA
PPWY
ITCH
0.2222
p.G92S
DO44429
HNSC
ICGC
PPWY
ITCH
0.2222
p.T78I
TCGA-W5-AA2I
CHOL
TCGA
PPWY
ITCH
0.1389
p.A82T
TCGA-ZF-A9R4
BLCA
TCGA
PPWY
ITCH
0.25
p.A82T
DO219061
BLCA
ICGC
PPWY
ITCH
0.25
p.G87S
DO222953
BTCA
ICGC
PPWY
ITCH
0.6993
p.G95R
DO233116
GACA
ICGC
PPWY
ITCH
0.5833
p.T97N
DO32596
OV
ICGC
PPWY
ITCH
0.0833
p.A85V
DO51795
STAD
ICGC
PPWY
ITCH
0.6936
p.S92I
DO42312
UCEC
ICGC
PPWY
ITCH
0.2222
p.E75G
ACH-001061
Colon/Colorectal Cancer
CCLE
PPWY
ITCH
0.0556
p.A85T
ACH-001518
Endometrial/Uterine Cancer
CCLE
PPWY
ITCH
0.7139
Drug responses associated with UCKL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPWY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6PFW1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
ITCH
1164:1167
PPWY
ITCH,NEDD4
0.8451
More...
Q96BZ8
Leukocyte receptor cluster member 1
ITCH
128:131
PPWY
ITCH,NEDD4
0.9953
More...
Q9GZV8
PR domain zinc finger protein 14
ITCH
99:102
PPWY
ITCH,NEDD4
0.5809
More...
Q9NWZ5
Uridine-cytidine kinase-like 1
ITCH
85:88
PPWY
ITCH,NEDD4
0.9964
More...