DegronMD - Q9GZV8(PRDM14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L43M	TCGA-62-A46P	LUAD	TCGA	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.711
p.L43M	DO25767	LUAD	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.711
p.P211H	TCGA-95-7039	LUAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7694
p.P211H	DO23907	LUAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7694
p.V205I	TCGA-AA-3527	COAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.V205I	DO9090	COAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.V205I	DO23268	LINC	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.V205I	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.A217T	TCGA-AD-A5EJ	COAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.25
p.A217T	DO50090	COAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.25
p.R54W	TCGA-AD-A5EJ	COAD	TCGA	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.R54W	DO50090	COAD	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.Y207C	TCGA-B0-5701	KIRC	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2778
p.Y207C	DO16240	KIRC	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2778
p.P211T	TCGA-BK-A139	UCEC	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7031
p.P211T	DO41716	UCEC	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7031
p.P34L	TCGA-BR-A4QL	STAD	TCGA	NLAAYYTPFP	CBL_PTK	25:34	Mutation altering degron motif	0.7582
p.P34L	DO38723	STAD	ICGC	NLAAYYTPFP	CBL_PTK	25:34	Mutation altering degron motif	0.7582
p.E200Q	TCGA-CU-A0YN	BLCA	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.0833
p.E200Q	DO488	BLCA	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.0833
p.G208R	TCGA-D1-A17M	UCEC	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.G208R	DO43779	UCEC	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.G208R	SIDM01128	Small Cell Lung Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.G208R	ACH-000767	Lung Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.G208R	NCI-H526	lung	COSMIC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.H106Y	TCGA-D3-A3C3	SKCM	TCGA	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1389
p.H106Y	TCGA-D3-A3C3	SKCM	TCGA	PPWY	ITCH	99:102	Mutation rewiring degron network	0.2222
p.H106Y	DO47667	SKCM	ICGC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1389
p.H106Y	DO47667	SKCM	ICGC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.2222
p.Q24H	TCGA-EO-A3AV	UCEC	TCGA	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.3056
p.Q24H	DO52412	UCEC	ICGC	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.3056
p.D201Y	TCGA-ER-A19F	SKCM	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1111
p.D201Y	DO37679	SKCM	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1111
p.H203P	TCGA-FS-A1Z3	SKCM	TCGA	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1667
p.H203P	DO37635	SKCM	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1667
p.P112L	TCGA-HI-7171	PRAD	TCGA	PPWY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.P112L	DO36312	PRAD	ICGC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.P103L	TCGA-LK-A4O6	MESO	TCGA	QREPLYDLP	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.0556
p.P103L	TCGA-LK-A4O6	MESO	TCGA	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.2222
p.P103L	TCGA-LK-A4O6	MESO	TCGA	PPWY	ITCH	99:102	Mutation rewiring degron network	0.3056
p.A28V	DO234340	ESAD	ICGC	NLAAYYTPFP	CBL_PTK	25:34	Mutation altering degron motif	0.5825
p.H220R	DO223149	ESCA	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1667
p.R109W	DO222649	ESCA	ICGC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.0556
p.R109W	DO222649	ESCA	ICGC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.1389
p.P19T	DO228948	LICA	ICGC	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.1667
p.H220N	DO228952	LICA	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1667
p.D201E	DO229028	LICA	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.1111
p.P88T	DO229028	LICA	ICGC	QREPLYDLP	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.5919
p.E47K	DO231559	LINC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.591
p.T45S	DO230968	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6005
p.T45S	DO224621	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6005
p.E110K	DO231114	LUSC	ICGC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.1111
p.D49E	DO231127	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.2778
p.P105S	DO222875	MELA	ICGC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105S	DO222875	MELA	ICGC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.G208K	DO222908	MELA	ICGC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.3056
p.A28T	SIDM01313	Colorectal Carcinoma	GDSC	NLAAYYTPFP	CBL_PTK	25:34	Mutation altering degron motif	0.6028
p.G81D	SIDM01169	Ovarian Carcinoma	GDSC	QREPLYDLP	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.2222
p.G81D	SIDM01169	Ovarian Carcinoma	GDSC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.0556
p.G81D	ACH-000885	Ovarian Cancer	CCLE	QREPLYDLP	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.2222
p.G81D	ACH-000885	Ovarian Cancer	CCLE	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.0556
p.F53C	SIDM00962	Chronic Myelogenous Leukemia	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.F53C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.F53C	SIDM01566	Hodgkin's Lymphoma	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.T210I	SIDM01174	Cervical Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7078
p.T210I	ACH-001402	Cervical Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7078
p.T210I	SW756	cervix	COSMIC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation altering degron motif	0.7078
p.R54Q	SIDM01112	Osteosarcoma	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.S218R	SIDM00844	Burkitt's Lymphoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.S218R	SIDM00954	Breast Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	209:214	Mutation rewiring degron network	0.2222
p.P105T	SIDM01257	Hepatocellular Carcinoma	GDSC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105T	SIDM01257	Hepatocellular Carcinoma	GDSC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.P105T	SIDM00062	Hepatocellular Carcinoma	GDSC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105T	SIDM00062	Hepatocellular Carcinoma	GDSC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.P105T	ACH-000671	Liver Cancer	CCLE	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105T	ACH-000671	Liver Cancer	CCLE	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.P105T	ACH-002395	Liver Cancer	CCLE	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105T	ACH-002395	Liver Cancer	CCLE	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.P105T	HUH-6-clone5	liver	COSMIC	DLPWYSKLP	CBL_PTK	91:99	Mutation rewiring degron network	0.1667
p.P105T	HUH-6-clone5	liver	COSMIC	PPWY	ITCH	99:102	Mutation rewiring degron network	0.25
p.Y102C	SIDM00217	Colorectal Carcinoma	GDSC	PPWY	ITCH	99:102	Mutation altering degron motif	0.7087
p.Y102C	SNU-1040	large intestine	COSMIC	PPWY	ITCH	99:102	Mutation altering degron motif	0.7087
p.Y36H	ACH-000219	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.Y36H	ACH-000219	Skin Cancer	CCLE	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.2778
p.Y36H	ACH-002001	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.Y36H	ACH-002001	Skin Cancer	CCLE	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.2778
p.Y36H	ACH-002002	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.Y36H	ACH-002002	Skin Cancer	CCLE	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.2778
p.Y36H	ACH-002003	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.Y36H	ACH-002003	Skin Cancer	CCLE	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.2778
p.P23L	ACH-000919	Gastric Cancer	CCLE	NLAAYYTPFP	CBL_PTK	25:34	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM14

UniProt ID: Q9GZV8

Entrez ID: 63978

Protein name: PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM14 in