DegronMD

Uniprot ID: Q9GZV8

Source protein: PR domain zinc finger protein 14

Source gene: PRDM14

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7365

ASA_SCORE: 56.2667

COIL: 0.4944

CONS_SCORE: 0.3699

DSS_SCORE: 0.3615

HELIX: 0.4399

FCONS_SCORE: 0.9829

RIG_SCORE: 0.765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L43M	TCGA-62-A46P	LUAD	TCGA	YRNSLATVE	DEG_APCC_DBOX_1	0.711
p.L43M	DO25767	LUAD	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.711
p.R54W	TCGA-AD-A5EJ	COAD	TCGA	YRNSLATVE	DEG_APCC_DBOX_1	0.1389
p.R54W	DO50090	COAD	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.1389
p.E47K	DO231559	LINC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.591
p.T45S	DO230968	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.6005
p.T45S	DO224621	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.6005
p.D49E	DO231127	LUSC	ICGC	YRNSLATVE	DEG_APCC_DBOX_1	0.2778
p.F53C	SIDM00962	Chronic Myelogenous Leukemia	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	0.1667
p.F53C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	0.1667
p.F53C	SIDM01566	Hodgkin's Lymphoma	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	0.1667
p.R54Q	SIDM01112	Osteosarcoma	GDSC	YRNSLATVE	DEG_APCC_DBOX_1	0.1389
p.Y36H	ACH-000219	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	0.25
p.Y36H	ACH-002001	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	0.25
p.Y36H	ACH-002002	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	0.25
p.Y36H	ACH-002003	Skin Cancer	CCLE	YRNSLATVE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZV8	PR domain zinc finger protein 14	DEG_APCC_DBOX_1	39:47	YRNSLATVE	APC,CDC20,FZR1	0.7365	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons