DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NLAAYYTPFP
Uniprot ID:
Q9GZV8
Source protein:
PR domain zinc finger protein 14
Source gene:
PRDM14
Class:
CBL_PTK
Location:
25:34
E3 ligase:
CBL
DEGRON score:
0.7927
ASA_SCORE:
32.38
COIL:
0.6087
CONS_SCORE:
0.3712
DSS_SCORE:
0.3677
HELIX:
0.1605
FCONS_SCORE:
1.05
RIG_SCORE:
0.7409
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P34L
TCGA-BR-A4QL
STAD
TCGA
NLAAYYTPFP
CBL_PTK
0.7582
p.P34L
DO38723
STAD
ICGC
NLAAYYTPFP
CBL_PTK
0.7582
p.A28T
SIDM01313
Colorectal Carcinoma
GDSC
NLAAYYTPFP
CBL_PTK
0.6028
p.A28V
DO234340
ESAD
ICGC
NLAAYYTPFP
CBL_PTK
0.5825
p.Q24H
TCGA-EO-A3AV
UCEC
TCGA
NLAAYYTPFP
CBL_PTK
0.3056
p.Q24H
DO52412
UCEC
ICGC
NLAAYYTPFP
CBL_PTK
0.3056
p.Y36H
ACH-000219
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002001
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002002
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002003
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.P23L
ACH-000919
Gastric Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.P19T
DO228948
LICA
ICGC
NLAAYYTPFP
CBL_PTK
0.1667
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Drug responses associated with PRDM14 mutations
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Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of NLAAYYTPFP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZV8
PR domain zinc finger protein 14
CBL_PTK
25:34
NLAAYYTPFP
CBL
0.7927
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