DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NLAAYYTPFP
Uniprot ID:
Q9GZV8
Source protein:
PR domain zinc finger protein 14
Source gene:
PRDM14
Class:
CBL_PTK
Location:
25:34
E3 ligase:
CBL
DEGRON score:
0.7927
ASA_SCORE:
32.38
COIL:
0.6087
CONS_SCORE:
0.3712
DSS_SCORE:
0.3677
HELIX:
0.1605
FCONS_SCORE:
1.05
RIG_SCORE:
0.7409
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P34L
TCGA-BR-A4QL
STAD
TCGA
NLAAYYTPFP
CBL_PTK
0.7582
p.P34L
DO38723
STAD
ICGC
NLAAYYTPFP
CBL_PTK
0.7582
p.Q24H
TCGA-EO-A3AV
UCEC
TCGA
NLAAYYTPFP
CBL_PTK
0.3056
p.Q24H
DO52412
UCEC
ICGC
NLAAYYTPFP
CBL_PTK
0.3056
p.A28V
DO234340
ESAD
ICGC
NLAAYYTPFP
CBL_PTK
0.5825
p.P19T
DO228948
LICA
ICGC
NLAAYYTPFP
CBL_PTK
0.1667
p.A28T
SIDM01313
Colorectal Carcinoma
GDSC
NLAAYYTPFP
CBL_PTK
0.6028
p.Y36H
ACH-000219
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002001
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002002
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.Y36H
ACH-002003
Skin Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
p.P23L
ACH-000919
Gastric Cancer
CCLE
NLAAYYTPFP
CBL_PTK
0.2778
Drug responses associated with PRDM14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLAAYYTPFP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZV8
PR domain zinc finger protein 14
CBL_PTK
25:34
NLAAYYTPFP
CBL
0.7927
More...
