DegronMD

Uniprot ID: Q9GZV8

Source protein: PR domain zinc finger protein 14

Source gene: PRDM14

Class: DEG_APCC_DBOX_1

Location: 85:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9911

ASA_SCORE: 76.7556

COIL: 0.8167

CONS_SCORE: 0.5275

DSS_SCORE: 0.1422

HELIX: 0.1123

FCONS_SCORE: 1.3616

RIG_SCORE: 0.7872

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P88T	DO229028	LICA	ICGC	QREPLYDLP	DEG_APCC_DBOX_1	0.5919
p.G81D	SIDM01169	Ovarian Carcinoma	GDSC	QREPLYDLP	DEG_APCC_DBOX_1	0.2222
p.G81D	ACH-000885	Ovarian Cancer	CCLE	QREPLYDLP	DEG_APCC_DBOX_1	0.2222
p.P103L	TCGA-LK-A4O6	MESO	TCGA	QREPLYDLP	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZV8	PR domain zinc finger protein 14	DEG_APCC_DBOX_1	85:93	QREPLYDLP	APC,CDC20,FZR1	0.9911	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons