DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QREPLYDLP
Uniprot ID:
Q9GZV8
Source protein:
PR domain zinc finger protein 14
Source gene:
PRDM14
Class:
DEG_APCC_DBOX_1
Location:
85:93
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9911
ASA_SCORE:
76.7556
COIL:
0.8167
CONS_SCORE:
0.5275
DSS_SCORE:
0.1422
HELIX:
0.1123
FCONS_SCORE:
1.3616
RIG_SCORE:
0.7872
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P103L
TCGA-LK-A4O6
MESO
TCGA
QREPLYDLP
DEG_APCC_DBOX_1
0.0556
p.P88T
DO229028
LICA
ICGC
QREPLYDLP
DEG_APCC_DBOX_1
0.5919
p.G81D
SIDM01169
Ovarian Carcinoma
GDSC
QREPLYDLP
DEG_APCC_DBOX_1
0.2222
p.G81D
ACH-000885
Ovarian Cancer
CCLE
QREPLYDLP
DEG_APCC_DBOX_1
0.2222
Drug responses associated with PRDM14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QREPLYDLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZV8
PR domain zinc finger protein 14
DEG_APCC_DBOX_1
85:93
QREPLYDLP
APC,CDC20,FZR1
0.9911
More...