DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLPWYSKLP
Uniprot ID:
Q9GZV8
Source protein:
PR domain zinc finger protein 14
Source gene:
PRDM14
Class:
CBL_PTK
Location:
91:99
E3 ligase:
CBL
DEGRON score:
0.5307
ASA_SCORE:
67.7778
COIL:
0.8122
CONS_SCORE:
0.4633
DSS_SCORE:
0.0895
HELIX:
0.0967
FCONS_SCORE:
1.08
RIG_SCORE:
0.7948
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H106Y
TCGA-D3-A3C3
SKCM
TCGA
DLPWYSKLP
CBL_PTK
0.1389
p.H106Y
DO47667
SKCM
ICGC
DLPWYSKLP
CBL_PTK
0.1389
p.P103L
TCGA-LK-A4O6
MESO
TCGA
DLPWYSKLP
CBL_PTK
0.2222
p.R109W
DO222649
ESCA
ICGC
DLPWYSKLP
CBL_PTK
0.0556
p.P105S
DO222875
MELA
ICGC
DLPWYSKLP
CBL_PTK
0.1667
p.G81D
SIDM01169
Ovarian Carcinoma
GDSC
DLPWYSKLP
CBL_PTK
0.0556
p.G81D
ACH-000885
Ovarian Cancer
CCLE
DLPWYSKLP
CBL_PTK
0.0556
p.P105T
SIDM01257
Hepatocellular Carcinoma
GDSC
DLPWYSKLP
CBL_PTK
0.1667
p.P105T
SIDM00062
Hepatocellular Carcinoma
GDSC
DLPWYSKLP
CBL_PTK
0.1667
p.P105T
ACH-000671
Liver Cancer
CCLE
DLPWYSKLP
CBL_PTK
0.1667
p.P105T
ACH-002395
Liver Cancer
CCLE
DLPWYSKLP
CBL_PTK
0.1667
p.P105T
HUH-6-clone5
liver
COSMIC
DLPWYSKLP
CBL_PTK
0.1667
Drug responses associated with PRDM14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLPWYSKLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZV8
PR domain zinc finger protein 14
CBL_PTK
91:99
DLPWYSKLP
CBL
0.5307
More...
