DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PPWY
Uniprot ID:
Q9GZV8
Source protein:
PR domain zinc finger protein 14
Source gene:
PRDM14
Class:
ITCH
Location:
99:102
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.5809
ASA_SCORE:
87.65
COIL:
0.9575
CONS_SCORE:
0.4589
DSS_SCORE:
0.1038
HELIX:
0.0118
FCONS_SCORE:
0.9957
RIG_SCORE:
0.7661
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H106Y
TCGA-D3-A3C3
SKCM
TCGA
PPWY
ITCH
0.2222
p.H106Y
DO47667
SKCM
ICGC
PPWY
ITCH
0.2222
p.P112L
TCGA-HI-7171
PRAD
TCGA
PPWY
ITCH
0.0556
p.P112L
DO36312
PRAD
ICGC
PPWY
ITCH
0.0556
p.P103L
TCGA-LK-A4O6
MESO
TCGA
PPWY
ITCH
0.3056
p.R109W
DO222649
ESCA
ICGC
PPWY
ITCH
0.1389
p.E110K
DO231114
LUSC
ICGC
PPWY
ITCH
0.1111
p.P105S
DO222875
MELA
ICGC
PPWY
ITCH
0.25
p.P105T
SIDM01257
Hepatocellular Carcinoma
GDSC
PPWY
ITCH
0.25
p.P105T
SIDM00062
Hepatocellular Carcinoma
GDSC
PPWY
ITCH
0.25
p.P105T
ACH-000671
Liver Cancer
CCLE
PPWY
ITCH
0.25
p.P105T
ACH-002395
Liver Cancer
CCLE
PPWY
ITCH
0.25
p.P105T
HUH-6-clone5
liver
COSMIC
PPWY
ITCH
0.25
p.Y102C
SIDM00217
Colorectal Carcinoma
GDSC
PPWY
ITCH
0.7087
p.Y102C
SNU-1040
large_intestine
COSMIC
PPWY
ITCH
0.7087
Drug responses associated with PRDM14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPWY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6PFW1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
ITCH
1164:1167
PPWY
ITCH,NEDD4
0.8451
More...
Q96BZ8
Leukocyte receptor cluster member 1
ITCH
128:131
PPWY
ITCH,NEDD4
0.9953
More...
Q9GZV8
PR domain zinc finger protein 14
ITCH
99:102
PPWY
ITCH,NEDD4
0.5809
More...
Q9NWZ5
Uridine-cytidine kinase-like 1
ITCH
85:88
PPWY
ITCH,NEDD4
0.9964
More...
