DegronMD

Uniprot ID: Q9GZV8

Source protein: PR domain zinc finger protein 14

Source gene: PRDM14

Class: DEG_SCF_FBW7_2

Location: 209:214

E3 ligase: FBXW7

DEGRON score: 0.988

ASA_SCORE: 66

COIL: 0.7857

CONS_SCORE: 0.4687

DSS_SCORE: 0.2644

HELIX: 0.0703

FCONS_SCORE: 0.7835

RIG_SCORE: 0.7229

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P211H	TCGA-95-7039	LUAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.7694
p.P211H	DO23907	LUAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.7694
p.V205I	TCGA-AA-3527	COAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.2222
p.V205I	DO9090	COAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.2222
p.V205I	DO23268	LINC	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.2222
p.V205I	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	0.2222
p.A217T	TCGA-AD-A5EJ	COAD	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.25
p.A217T	DO50090	COAD	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.25
p.Y207C	TCGA-B0-5701	KIRC	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.2778
p.Y207C	DO16240	KIRC	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.2778
p.P211T	TCGA-BK-A139	UCEC	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.7031
p.P211T	DO41716	UCEC	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.7031
p.E200Q	TCGA-CU-A0YN	BLCA	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.0833
p.E200Q	DO488	BLCA	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.0833
p.G208R	TCGA-D1-A17M	UCEC	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.G208R	DO43779	UCEC	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.G208R	SIDM01128	Small Cell Lung Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.G208R	ACH-000767	Lung Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.G208R	NCI-H526	lung	COSMIC	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.D201Y	TCGA-ER-A19F	SKCM	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.1111
p.D201Y	DO37679	SKCM	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.1111
p.H203P	TCGA-FS-A1Z3	SKCM	TCGA	VTPSLE	DEG_SCF_FBW7_2	0.1667
p.H203P	DO37635	SKCM	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.1667
p.H220R	DO223149	ESCA	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.1667
p.H220N	DO228952	LICA	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.1667
p.D201E	DO229028	LICA	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.1111
p.G208K	DO222908	MELA	ICGC	VTPSLE	DEG_SCF_FBW7_2	0.3056
p.T210I	SIDM01174	Cervical Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	0.7078
p.T210I	ACH-001402	Cervical Cancer	CCLE	VTPSLE	DEG_SCF_FBW7_2	0.7078
p.T210I	SW756	cervix	COSMIC	VTPSLE	DEG_SCF_FBW7_2	0.7078
p.S218R	SIDM00844	Burkitt's Lymphoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	0.2222
p.S218R	SIDM00954	Breast Carcinoma	GDSC	VTPSLE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPSLE

Degron related mutations and impact score

Drug responses associated with PRDM14 mutations

All proteins holding degron of VTPSLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZV8	PR domain zinc finger protein 14	DEG_SCF_FBW7_2	209:214	VTPSLE	FBXW7	0.988	More...