DegronMD - Q8TDF5(NETO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P499T	TCGA-17-Z055	LUAD	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.5919
p.D509N	TCGA-18-3409	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	TCGA-19-5956	GBM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	TCGA-AP-A0LM	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	TCGA-EB-A51B	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	TCGA-EE-A2MS	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	TCGA-OR-A5KY	ACC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	SIDM00003	Melanoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	ACH-002159	Skin Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.D509N	M14	skin	COSMIC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1389
p.R507I	TCGA-77-7465	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.D488N	TCGA-A2-A25A	BRCA	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.R504M	TCGA-B5-A3FA	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.P499L	TCGA-CM-6171	COAD	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6471
p.H508L	TCGA-CR-7402	HNSC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.V498M	TCGA-DA-A1HV	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7208
p.E496K	TCGA-DA-A3F3	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.E496K	TCGA-EO-A22U	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.H508Q	TCGA-E2-A1IH	BRCA	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.E494K	TCGA-EE-A20C	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.E494K	TCGA-EE-A2GJ	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.T500A	TCGA-IN-7806	STAD	TCGA	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7139
p.H507Q	DO2983	BRCA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.P498L	DO8151	COAD	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7582
p.V511I	DO228094	EOPC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.V511I	DO229053	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.D508N	DO13863	GBM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D508N	DO26444	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D508N	DO222753	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D508N	DO37567	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D508N	DO47343	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D508N	DO43306	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.H507L	DO15727	HNSC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.R506I	DO27699	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.E493K	DO222775	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.E493K	DO37746	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.E493K	DO47665	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.Q512H	DO46657	PAAD	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.T500S	DO51527	PACA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6005
p.V497M	DO37659	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.E495K	DO37607	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25
p.E495K	DO43755	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25
p.T499A	DO38831	STAD	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7139
p.R506K	DO229275	THCA	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.R503M	DO52402	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.V512I	SIDM00450	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00435	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00234	Other Solid Cancers	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00352	Ovarian Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00604	Oral Cavity Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00026	Other Solid Cancers	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM01682	Gastric Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM01660	Kidney Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM01447	Glioblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00959	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.V512I	SIDM00016	Neuroblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.I495N	SIDM00779	Colorectal Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25
p.I495N	ACH-000491	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25
p.I495N	NCI-H716	large intestine	COSMIC	VPTTS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NETO1

UniProt ID: Q8TDF5

Entrez ID: 81832

Protein name: Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NETO1 in