DegronMD

Uniprot ID: Q8TDF5

Source protein: Neuropilin and tolloid-like protein 1

Source gene: NETO1

Class: DEG_SPOP_SBC_1

Location: 498:502

E3 ligase: SPOP

DEGRON score: 0.9808

ASA_SCORE: 65.6

COIL: 0.8208

CONS_SCORE: 0.3271

DSS_SCORE: 0.418

HELIX: 0.0648

FCONS_SCORE: 0.8918

RIG_SCORE: 0.7413

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P499T	TCGA-17-Z055	LUAD	TCGA	VPTTS	DEG_SPOP_SBC_1	0.5919
p.D509N	TCGA-18-3409	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	TCGA-19-5956	GBM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	TCGA-AP-A0LM	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	TCGA-EB-A51B	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	TCGA-EE-A2MS	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	TCGA-OR-A5KY	ACC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	SIDM00003	Melanoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	ACH-002159	Skin Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.1389
p.D509N	M14	skin	COSMIC	VPTTS	DEG_SPOP_SBC_1	0.1389
p.R507I	TCGA-77-7465	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1944
p.D488N	TCGA-A2-A25A	BRCA	TCGA	VPTTS	DEG_SPOP_SBC_1	0.0556
p.R504M	TCGA-B5-A3FA	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.2778
p.P499L	TCGA-CM-6171	COAD	TCGA	VPTTS	DEG_SPOP_SBC_1	0.6471
p.H508L	TCGA-CR-7402	HNSC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1667
p.V498M	TCGA-DA-A1HV	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.7208
p.E496K	TCGA-DA-A3F3	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.2778
p.E496K	TCGA-EO-A22U	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	0.2778
p.H508Q	TCGA-E2-A1IH	BRCA	TCGA	VPTTS	DEG_SPOP_SBC_1	0.1667
p.E494K	TCGA-EE-A20C	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.2222
p.E494K	TCGA-EE-A2GJ	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	0.2222
p.T500A	TCGA-IN-7806	STAD	TCGA	VPTTS	DEG_SPOP_SBC_1	0.7139
p.H507Q	DO2983	BRCA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.P498L	DO8151	COAD	ICGC	VPTTS	DEG_SPOP_SBC_1	0.7582
p.V511I	DO228094	EOPC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.0833
p.V511I	DO229053	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.0833
p.D508N	DO13863	GBM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.D508N	DO26444	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.D508N	DO222753	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.D508N	DO37567	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.D508N	DO47343	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.D508N	DO43306	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1667
p.H507L	DO15727	HNSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.R506I	DO27699	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.2222
p.E493K	DO222775	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.E493K	DO37746	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.E493K	DO47665	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.1944
p.Q512H	DO46657	PAAD	ICGC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.T500S	DO51527	PACA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.6005
p.V497M	DO37659	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.3056
p.E495K	DO37607	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	0.25
p.E495K	DO43755	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.25
p.T499A	DO38831	STAD	ICGC	VPTTS	DEG_SPOP_SBC_1	0.7139
p.R506K	DO229275	THCA	ICGC	VPTTS	DEG_SPOP_SBC_1	0.2222
p.R503M	DO52402	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	0.3056
p.V512I	SIDM00450	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00435	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00234	Other Solid Cancers	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00352	Ovarian Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00604	Oral Cavity Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00026	Other Solid Cancers	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM01682	Gastric Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM01660	Kidney Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM01447	Glioblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00959	Acute Myeloid Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.V512I	SIDM00016	Neuroblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556
p.I495N	SIDM00779	Colorectal Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.25
p.I495N	ACH-000491	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	0.25
p.I495N	NCI-H716	large_intestine	COSMIC	VPTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	370:374	VPTTS	SPOP	0.8558	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2399:2403	VPTTS	SPOP	0.8982	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2495:2499	VPTTS	SPOP	0.7928	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2575:2579	VPTTS	SPOP	0.5198	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2671:2675	VPTTS	SPOP	0.9448	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2839:2843	VPTTS	SPOP	0.9083	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2935:2939	VPTTS	SPOP	0.9476	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2951:2955	VPTTS	SPOP	0.798	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2959:2963	VPTTS	SPOP	0.6777	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3071:3075	VPTTS	SPOP	0.6444	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3159:3163	VPTTS	SPOP	0.5848	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3191:3195	VPTTS	SPOP	0.7503	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3922:3926	VPTTS	SPOP	0.7805	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4228:4232	VPTTS	SPOP	0.9669	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4300:4304	VPTTS	SPOP	0.9127	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4324:4328	VPTTS	SPOP	0.7065	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4444:4448	VPTTS	SPOP	0.8216	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4516:4520	VPTTS	SPOP	0.9642	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4596:4600	VPTTS	SPOP	0.5935	More...
Q05707	Collagen alpha-1	DEG_SPOP_SBC_1	725:729	VPTTS	SPOP	0.9814	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	1284:1288	VPTTS	SPOP	0.9896	More...
Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	DEG_SPOP_SBC_1	381:385	VPTTS	SPOP	0.942	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	395:399	VPTTS	SPOP	0.9894	More...
Q8N5I2	Arrestin domain-containing protein 1	DEG_SPOP_SBC_1	393:397	VPTTS	SPOP	0.995	More...
Q8TDF5	Neuropilin and tolloid-like protein 1	DEG_SPOP_SBC_1	498:502	VPTTS	SPOP	0.9808	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13290:13294	VPTTS	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13602:13606	VPTTS	SPOP	0.9442	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13913:13917	VPTTS	SPOP	0.8716	More...
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	66:70	VPTTS	SPOP	0.9982	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	3459:3463	VPTTS	SPOP	0.9438	More...
Q9HBW1	Leucine-rich repeat-containing protein 4	DEG_SPOP_SBC_1	476:480	VPTTS	SPOP	0.9425	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	158:162	VPTTS	SPOP	0.9979	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1828:1832	VPTTS	SPOP	0.5647	More...
Q9NU02	Ankyrin repeat and EF-hand domain-containing protein 1	DEG_SPOP_SBC_1	687:691	VPTTS	SPOP	0.9845	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_SPOP_SBC_1	257:261	VPTTS	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTS

Degron related mutations and impact score

Drug responses associated with NETO1 mutations

All proteins holding degron of VPTTS