DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 3922:3926

E3 ligase: SPOP

DEGRON score: 0.7805

ASA_SCORE: 85.74

COIL: 0.8858

CONS_SCORE: 0.3008

DSS_SCORE: 0.6136

HELIX: 0.0146

FCONS_SCORE: 1.0039

RIG_SCORE: 0.6308

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3923S	SIDM01175	Other Sarcomas	GDSC	VPTTS	DEG_SPOP_SBC_1	0.5641
p.K3932N	SIDM00741	Small Cell Lung Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.2778
p.K3932N	SIDM00948	Burkitt's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.2778
p.K3932N	SIDM00201	Ewing's Sarcoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.2778
p.S3936T	SIDM00574	Glioblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 5 of 5 entries

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Drug responses associated with MUC5AC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VPTTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NU02	Ankyrin repeat and EF-hand domain-containing protein 1	DEG_SPOP_SBC_1	687:691	VPTTS	SPOP	0.9845	More...
Q8N5I2	Arrestin domain-containing protein 1	DEG_SPOP_SBC_1	393:397	VPTTS	SPOP	0.995	More...
Q05707	Collagen alpha-1	DEG_SPOP_SBC_1	725:729	VPTTS	SPOP	0.9814	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	1284:1288	VPTTS	SPOP	0.9896	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	395:399	VPTTS	SPOP	0.9894	More...
Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	DEG_SPOP_SBC_1	381:385	VPTTS	SPOP	0.942	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	370:374	VPTTS	SPOP	0.8558	More...
Q9HBW1	Leucine-rich repeat-containing protein 4	DEG_SPOP_SBC_1	476:480	VPTTS	SPOP	0.9425	More...
Q96AG3	Mitochondrial outer membrane protein SLC25A46	DEG_SPOP_SBC_1	66:70	VPTTS	SPOP	0.9982	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	3459:3463	VPTTS	SPOP	0.9438	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13290:13294	VPTTS	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13602:13606	VPTTS	SPOP	0.9442	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13913:13917	VPTTS	SPOP	0.8716	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2399:2403	VPTTS	SPOP	0.8982	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2495:2499	VPTTS	SPOP	0.7928	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2575:2579	VPTTS	SPOP	0.5198	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2671:2675	VPTTS	SPOP	0.9448	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2839:2843	VPTTS	SPOP	0.9083	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2935:2939	VPTTS	SPOP	0.9476	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2951:2955	VPTTS	SPOP	0.798	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2959:2963	VPTTS	SPOP	0.6777	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3071:3075	VPTTS	SPOP	0.6444	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3159:3163	VPTTS	SPOP	0.5848	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3191:3195	VPTTS	SPOP	0.7503	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3922:3926	VPTTS	SPOP	0.7805	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTS

Degron related mutations and impact score

Drug responses associated with MUC5AC mutations

All proteins holding degron of VPTTS