DegronMD - Q05707(COL14A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D583Y	TCGA-39-5035	LUSC	TCGA	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.D583Y	DO27310	LUSC	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.F716L	TCGA-43-8116	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.0833
p.F716L	DO27349	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.0833
p.D583N	TCGA-A5-A0G2	UCEC	TCGA	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.D583N	DO222418	MELA	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.D583N	DO41235	UCEC	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.D583N	SIDM01608	Endometrial Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.D583N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.0556
p.E598D	TCGA-AZ-4315	COAD	TCGA	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation altering degron motif	0.6758
p.E598D	DO8842	COAD	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation altering degron motif	0.6758
p.Q735H	TCGA-VS-A8QA	CESC	TCGA	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1667
p.Q735H	DO51627	CESC	ICGC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1667
p.G737R	DO220903	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1111
p.G737R	SIDM01090	Colorectal Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1111
p.G737R	ACH-000943	Colon/Colorectal Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1111
p.G737R	RKO	large intestine	COSMIC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1111
p.TG736TR	DO220903	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0
p.T600A	DO229155	NKTL	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2778
p.T600A	SIDM01018	Hodgkin's Lymphoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2778
p.T600A	ACH-000815	Lymphoma	CCLE	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2778
p.T600A	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2778
p.I585T	DO232570	PBCA	ICGC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1111
p.T718A	DO229259	THCA	ICGC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1389
p.A602S	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.A602S	ACH-000920	Leukemia	CCLE	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.A602S	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.T586A	SIDM00091	Ovarian Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1389
p.T586A	SIDM00143	Small Cell Lung Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1389
p.T586A	SIDM01322	Oral Cavity Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1389
p.T728I	SIDM00272	Breast Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.7078
p.T728I	ACH-000910	Breast Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.7078
p.T728I	MDA-MB-453	breast	COSMIC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.7078
p.P589H	SIDM00537	Colorectal Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.P589H	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.P589H	GP5d	large intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.2222
p.I585V	SIDM00118	Colorectal Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1111
p.I585V	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1111
p.I585V	HCC2998	large intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation rewiring degron network	0.1111
p.E719D	ACH-000785	Lung Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1667
p.E719D	NCI-H2126	lung	COSMIC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1667
p.G729C	MDST8	large intestine	COSMIC	VPTTS	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.76
p.Y596H	SNU-C5	large intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	593:598	Mutation altering degron motif	0.7229

Kaplan plot for COL14A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL14A1

UniProt ID: Q05707

Entrez ID: 7373

Protein name: Collagen alpha-1(XIV) chain (Undulin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL14A1 in