DegronMD

Uniprot ID: Q05707

Source protein: Collagen alpha-1

Source gene: COL14A1

Class: DEG_SCF_FBW7_2

Location: 593:598

E3 ligase: FBXW7

DEGRON score: 0.7327

ASA_SCORE: 61.8667

COIL: 0.8217

CONS_SCORE: 0.6609

DSS_SCORE: 0.0983

HELIX: 0.008

FCONS_SCORE: 1.3471

RIG_SCORE: 0.8608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D583Y	TCGA-39-5035	LUSC	TCGA	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583Y	DO27310	LUSC	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583N	TCGA-A5-A0G2	UCEC	TCGA	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583N	DO222418	MELA	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583N	DO41235	UCEC	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583N	SIDM01608	Endometrial Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.D583N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	0.0556
p.E598D	TCGA-AZ-4315	COAD	TCGA	LTPLTE	DEG_SCF_FBW7_2	0.6758
p.E598D	DO8842	COAD	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.6758
p.T600A	DO229155	NKTL	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.2778
p.T600A	SIDM01018	Hodgkin's Lymphoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.2778
p.T600A	ACH-000815	Lymphoma	CCLE	LTPLTE	DEG_SCF_FBW7_2	0.2778
p.T600A	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLTE	DEG_SCF_FBW7_2	0.2778
p.I585T	DO232570	PBCA	ICGC	LTPLTE	DEG_SCF_FBW7_2	0.1111
p.A602S	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.A602S	ACH-000920	Leukemia	CCLE	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.A602S	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.T586A	SIDM00091	Ovarian Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.1389
p.T586A	SIDM00143	Small Cell Lung Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.1389
p.T586A	SIDM01322	Oral Cavity Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.1389
p.P589H	SIDM00537	Colorectal Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.P589H	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.P589H	GP5d	large_intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	0.2222
p.I585V	SIDM00118	Colorectal Carcinoma	GDSC	LTPLTE	DEG_SCF_FBW7_2	0.1111
p.I585V	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPLTE	DEG_SCF_FBW7_2	0.1111
p.I585V	HCC2998	large_intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	0.1111
p.Y596H	SNU-C5	large_intestine	COSMIC	LTPLTE	DEG_SCF_FBW7_2	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLTE

Degron related mutations and impact score

Drug responses associated with COL14A1 mutations

All proteins holding degron of LTPLTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05707	Collagen alpha-1	DEG_SCF_FBW7_2	593:598	LTPLTE	FBXW7	0.7327	More...