DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: DEG_SCF_FBW7_1

Location: 323:328

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 85.1167

COIL: 0.9598

CONS_SCORE: 0.3636

DSS_SCORE: 0.6573

HELIX: 0.0148

FCONS_SCORE: 0.9844

RIG_SCORE: 0.6751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V333L	TCGA-05-5423	LUAD	TCGA	VTPELT	DEG_SCF_FBW7_1	0.1944
p.P320A	TCGA-22-4596	LUSC	TCGA	VTPELT	DEG_SCF_FBW7_1	0.25
p.V334M	TCGA-A5-A0G2	UCEC	TCGA	VTPELT	DEG_SCF_FBW7_1	0.1667
p.S319F	TCGA-DA-A1HV	SKCM	TCGA	VTPELT	DEG_SCF_FBW7_1	0.6667
p.S319T	TCGA-DQ-7592	HNSC	TCGA	VTPELT	DEG_SCF_FBW7_1	0.6667
p.E331K	TCGA-EB-A3XC	SKCM	TCGA	VTPELT	DEG_SCF_FBW7_1	0.25
p.P320L	TCGA-G9-A9S4	PRAD	TCGA	VTPELT	DEG_SCF_FBW7_1	0.25
p.P320L	SIDM00985	Burkitt's Lymphoma	GDSC	VTPELT	DEG_SCF_FBW7_1	0.25
p.P320L	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.25
p.P329T	TCGA-MN-A4N4	LUAD	TCGA	VTPELT	DEG_SCF_FBW7_1	0.3056
p.D333G	DO227941	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.1944
p.A313E	DO1434	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.0556
p.G314W	DO5326	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.0833
p.P336S	DO233791	GACA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.1111
p.P329L	DO233870	GACA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.S323T	DO14157	HNSC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7116
p.V337L	DO26132	LUAD	ICGC	VTPELT	DEG_SCF_FBW7_1	0.0833
p.P333T	DO26250	LUAD	ICGC	VTPELT	DEG_SCF_FBW7_1	0.1944
p.P324A	DO27739	LUSC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7503
p.Y329C	DO27208	LUSC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.G327R	DO220912	MELA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7568
p.G327E	DO222670	MELA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7199
p.G327E	DO38057	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7199
p.S323F	DO218211	ORCA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7982
p.S323F	DO37659	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7982
p.V330I	DO33368	PACA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.2778
p.P324L	DO51340	PRAD	ICGC	VTPELT	DEG_SCF_FBW7_1	0.7582
p.P324L	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.7582
p.D329N	DO229456	SKCA	ICGC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.E335K	DO37579	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	0.5833
p.A325V	DO38551	STAD	ICGC	VTPELT	DEG_SCF_FBW7_1	0.6936
p.A325V	DO42673	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.6936
p.V338M	DO41235	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.0556
p.R316Q	DO41235	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	0.5833
p.P329Q	SIDM00792	Small Cell Lung Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.P329Q	SIDM01588	Endometrial Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.P329Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	0.3056
p.P329Q	ACH-002170	Lung Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	0.3056
p.P329Q	NCI-H1688	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.3056
p.V334L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	0.1667
p.V334L	ACH-000852	Lung Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	0.1667
p.V334L	NCI-H1435	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.1667
p.A313V	KATOIII	stomach	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.0556
p.V338L	NCI-H1435	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.0556
p.P333Q	NCI-H1688	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPELT

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of VTPELT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SCF_FBW7_1	323:328	VTPELT	FBXW7	0.9924	More...