DegronMD

Uniprot ID: Q9UQR0

Source protein: Sex comb on midleg-like protein 2

Source gene: SCML2

Class: DEG_COP1_1

Location: 606:617

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 74.4417

COIL: 0.8069

CONS_SCORE: 0.7156

DSS_SCORE: 0.4738

HELIX: 0.0832

FCONS_SCORE: 1.0173

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H596L	TCGA-49-4506	LUAD	TCGA	SEAPSYIAVPDP	DEG_COP1_1	0.0556
p.H596L	DO25084	LUAD	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.0556
p.A613T	TCGA-AJ-A3OL	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	0.6028
p.A613T	DO43001	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.6028
p.P617H	TCGA-AP-A056	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	0.7694
p.P617H	DO43971	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.7694
p.K626N	TCGA-BS-A0UV	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	0.1944
p.K626N	DO42793	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.1944
p.D627A	TCGA-EE-A2A2	SKCM	TCGA	SEAPSYIAVPDP	DEG_COP1_1	0.0556
p.D627A	DO37583	SKCM	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.0556
p.P617T	DO229029	LICA	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.7031
p.S606R	DO220849	MELA	ICGC	SEAPSYIAVPDP	DEG_COP1_1	0.8538
p.S625C	SIDM00845	Burkitt's Lymphoma	GDSC	SEAPSYIAVPDP	DEG_COP1_1	0.1111
p.S625C	SIDM00461	Acute Myeloid Leukemia	GDSC	SEAPSYIAVPDP	DEG_COP1_1	0.1111
p.S625C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SEAPSYIAVPDP	DEG_COP1_1	0.1111
p.S625C	ACH-000786	Lymphoma	CCLE	SEAPSYIAVPDP	DEG_COP1_1	0.1111
p.S625C	ACH-000992	Head and Neck Cancer	CCLE	SEAPSYIAVPDP	DEG_COP1_1	0.1111
p.S625C	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SEAPSYIAVPDP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQR0	Sex comb on midleg-like protein 2	DEG_COP1_1	606:617	SEAPSYIAVPDP	COP1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons