DegronMD

Uniprot ID: Q15811

Source protein: Intersectin-1

Source gene: ITSN1

Class: DEG_SCF_TRCP1_1

Location: 980:986

E3 ligase: BTRC

DEGRON score: 0.9594

ASA_SCORE: 79.2857

COIL: 0.9201

CONS_SCORE: 0.2444

DSS_SCORE: 0.5255

HELIX: 0.0557

FCONS_SCORE: 1.0105

RIG_SCORE: 0.5759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I973V	TCGA-50-5939	LUAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	TCGA-EI-6882	READ	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	DO25183	LUAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	DO36531	READ	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.I973V	SIDM01519	Head and Neck Carcinoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	0.1389
p.K975R	TCGA-BR-8687	STAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.3056
p.K975R	DO47801	STAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.3056
p.R992Q	TCGA-CK-4951	COAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.1667
p.R992Q	DO10582	COAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.1667
p.S981A	TCGA-D1-A16X	UCEC	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.87
p.S981A	DO41799	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.87
p.S978I	TCGA-E6-A2P8	UCEC	TCGA	DSGSSES	DEG_SCF_TRCP1_1	0.7222
p.S978I	DO45096	LIRI	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.7222
p.S978I	DO40924	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.7222
p.G980S	DO225287	BRCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.6993
p.G980S	DO227892	BRCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.6993
p.P972S	DO50336	ESAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.1111
p.N996D	DO233871	GACA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.0556
p.H983Y	DO220906	MELA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.7229
p.P970L	DO218874	SKCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.5
p.L987I	DO41758	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	0.3056
p.V996I	ACH-000750	Skin Cancer	CCLE	DSGSSES	DEG_SCF_TRCP1_1	0.0556
p.V996I	LOXIMVI	skin	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	0.0556
p.L988V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	0.2778
p.L988V	S-117	soft_tissue	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	0.2778
p.H983N	SNU-81	large_intestine	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSES

Degron related mutations and impact score

Drug responses associated with ITSN1 mutations

All proteins holding degron of DSGSSES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15811	Intersectin-1	DEG_SCF_TRCP1_1	980:986	DSGSSES	BTRC	0.9594	More...