DegronMD

Uniprot ID: Q9HDC5

Source protein: Junctophilin-1

Source gene: JPH1

Class: DEG_APCC_KENBOX_2

Location: 434:438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8024

ASA_SCORE: 95.8

COIL: 0.8512

CONS_SCORE: 0.2757

DSS_SCORE: 0.7066

HELIX: 0.1342

FCONS_SCORE: 0.9418

RIG_SCORE: 0.6238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K441N	TCGA-37-3792	LUSC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441N	DO27192	LUSC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.E440K	TCGA-C5-A1MH	CESC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.2778
p.E440K	DO48982	CESC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.2778
p.P438L	DO220891	MELA	ICGC	AKENP	DEG_APCC_KENBOX_2	0.6471
p.V442I	DO222653	MELA	ICGC	AKENP	DEG_APCC_KENBOX_2	0.2222
p.V424I	SIDM00521	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.0556
p.K441R	SIDM01126	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM00878	Breast Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM00721	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM01140	Ovarian Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM00257	Neuroblastoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM00808	Burkitt's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K441R	SIDM01254	Burkitt's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.3611
p.K435N	SIDM00118	Colorectal Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.6918
p.K435N	ACH-001081	Colon/Colorectal Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.6918
p.K435N	HCC2998	large_intestine	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.6918
p.R427I	SIDM01472	Hepatocellular Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1389
p.R427I	ACH-000471	Liver Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1389
p.Q426R	ACH-001736	Leukemia	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_APCC_KENBOX_2	4:8	AKENP	APC,CDC20,FZR1	0.9545	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	1253:1257	AKENP	APC,CDC20,FZR1	0.9045	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_APCC_KENBOX_2	423:427	AKENP	APC,CDC20,FZR1	0.7516	More...
Q9HDC5	Junctophilin-1	DEG_APCC_KENBOX_2	434:438	AKENP	APC,CDC20,FZR1	0.8024	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_APCC_KENBOX_2	181:185	AKENP	APC,CDC20,FZR1	0.9628	More...
Q96SY0	Integrator complex subunit 14	DEG_APCC_KENBOX_2	375:379	AKENP	APC,CDC20,FZR1	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons