DegronMD - Q9HDC5(JPH1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K351I	TCGA-05-4390	LUAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation substituting flanking lysine	0.3611
p.K351I	DO23562	LUAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation substituting flanking lysine	0.3611
p.T350S	TCGA-05-4390	LUAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.T350S	DO23562	LUAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.K441N	TCGA-37-3792	LUSC	TCGA	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441N	TCGA-37-3792	LUSC	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441N	DO27192	LUSC	ICGC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441N	DO27192	LUSC	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.G150V	TCGA-56-8307	LUSC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.G150V	DO219139	LUSC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.E545D	TCGA-AA-3715	COAD	TCGA	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.6758
p.E545D	DO8018	COAD	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.6758
p.R167C	TCGA-AP-A051	UCEC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.719
p.R167C	DO42673	UCEC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.719
p.S548F	TCGA-B5-A1MR	UCEC	TCGA	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation blocking phosphorylation signal	0.6944
p.S548F	DO41758	UCEC	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation blocking phosphorylation signal	0.6944
p.R160P	TCGA-BA-4076	HNSC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7512
p.R160P	DO14502	HNSC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7512
p.E440K	TCGA-C5-A1MH	CESC	TCGA	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.2778
p.E440K	TCGA-C5-A1MH	CESC	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1667
p.E440K	DO48982	CESC	ICGC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.2778
p.E440K	DO48982	CESC	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1667
p.D357G	TCGA-CM-4748	COAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0833
p.D357G	DO10614	COAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0833
p.T161S	TCGA-DK-A2I4	BLCA	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7116
p.T161S	DO465	BLCA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7116
p.G150S	TCGA-DX-A7EU	SARC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.G150S	DO220040	SARC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.R338C	TCGA-EE-A2MJ	SKCM	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.R338C	DO38099	SKCM	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.S162L	TCGA-EE-A2MR	SKCM	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.S162L	DO51110	PRAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.S162L	DO37819	SKCM	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.R457C	TCGA-EE-A3JE	SKCM	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R457C	TCGA-FI-A2D0	UCEC	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R457C	DO48766	SKCM	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R457C	DO43891	UCEC	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R457C	SIDM01588	Endometrial Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R457C	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.T153M	TCGA-FJ-A3Z9	BLCA	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation blocking phosphorylation signal	0.6111
p.T153M	DO44065	BLCA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation blocking phosphorylation signal	0.6111
p.Y456N	TCGA-FW-A3R5	SKCM	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.2222
p.Y456N	DO37406	SKCM	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.2222
p.A152V	TCGA-HU-A4GU	STAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1389
p.A152V	DO47849	STAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1389
p.R167H	TCGA-IB-A7LX	PAAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7133
p.R167H	DO50260	PAAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7133
p.R156H	TCGA-MX-A5UJ	STAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.25
p.R156H	DO234155	ESAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.25
p.R156H	DO48547	STAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.25
p.P449S	TCGA-VQ-A8PP	STAD	TCGA	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation altering degron motif	0.6752
p.P449S	DO51774	STAD	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation altering degron motif	0.6752
p.G544R	TCGA-VS-A9UB	CESC	TCGA	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.7568
p.G544R	DO219731	CESC	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.7568
p.G544R	SIDM00479	Esophageal Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.7568
p.G544R	OE19	oesophagus	COSMIC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.7568
p.T460A	DO225086	BRCA	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation blocking phosphorylation signal	0.5556
p.R535C	DO223416	CLLE	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.R160H	DO50434	ESAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8244
p.R160H	DO233272	GACA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8244
p.V555M	DO234275	ESAD	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.0556
p.V555A	DO233146	GACA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.0556
p.L163R	DO233884	GACA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8428
p.N543K	DO228986	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.6918
p.R535S	DO229015	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.H537N	DO229037	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.25
p.V356M	DO23192	LINC	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111
p.R160C	DO48701	LIRI	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8301
p.H454Y	DO231124	LUSC	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.2778
p.G339R	DO220886	MELA	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.P438L	DO220891	MELA	ICGC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation altering degron motif	0.6471
p.V442I	DO222653	MELA	ICGC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.2222
p.V442I	DO222653	MELA	ICGC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.2222
p.E545K	DO229462	SKCA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation altering degron motif	0.7022
p.A164T	DO41199	UCEC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6028
p.I335N	SIDM00313	Hodgkin's Lymphoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1944
p.I335N	ACH-000702	Lymphoma	CCLE	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1944
p.I335N	L-1236	haematopoietic and lymphoid tissue	COSMIC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1944
p.V424I	SIDM00521	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.0556
p.H349N	SIDM00845	Burkitt's Lymphoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.H349N	SIDM00035	Thyroid Gland Carcinoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.H349N	SIDM01519	Head and Neck Carcinoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.H349N	ACH-000786	Lymphoma	CCLE	IRKQLIPIR	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.K441R	SIDM01126	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM00878	Breast Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM00878	Breast Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM00721	Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM01140	Ovarian Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM01140	Ovarian Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM00257	Neuroblastoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM00257	Neuroblastoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM00808	Burkitt's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM00808	Burkitt's Lymphoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.K441R	SIDM01254	Burkitt's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation substituting flanking lysine	0.3611
p.K441R	SIDM01254	Burkitt's Lymphoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation substituting flanking lysine	0.3056
p.P453H	SIDM01229	Neuroblastoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.P453H	BE2-M17	autonomic ganglia	COSMIC	PPTPKES	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.R535L	SIDM00721	Small Cell Lung Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.R535L	ACH-002171	Lung Cancer	CCLE	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.R535L	NCI-H250	lung	COSMIC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.K435N	SIDM00118	Colorectal Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation altering degron motif	0.6918
p.K435N	ACH-001081	Colon/Colorectal Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation altering degron motif	0.6918
p.K435N	HCC2998	large intestine	COSMIC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation altering degron motif	0.6918
p.R427I	SIDM01472	Hepatocellular Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.1389
p.R427I	ACH-000471	Liver Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.1389
p.R535H	SIDM01443	Gastric Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.R535H	ACH-000344	Gastric Cancer	CCLE	NPSNGE	DEG_Kelch_Keap1_1	540:545	Mutation rewiring degron network	0.1944
p.Q426R	ACH-001736	Leukemia	CCLE	AKENP	DEG_APCC_KENBOX_2	434:438	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JPH1

UniProt ID: Q9HDC5

Entrez ID: 56704

Protein name: Junctophilin-1 (JP-1) (Junctophilin type 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JPH1 in