DegronMD

Uniprot ID: Q9HDC5

Source protein: Junctophilin-1

Source gene: JPH1

Class: DEG_APCC_DBOX_1

Location: 340:348

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5348

ASA_SCORE: 77.5444

COIL: 0.4649

CONS_SCORE: 0.4012

DSS_SCORE: 0.3959

HELIX: 0.0078

FCONS_SCORE: 0.8888

RIG_SCORE: 0.8291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K351I	TCGA-05-4390	LUAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	0.3611
p.K351I	DO23562	LUAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.3611
p.T350S	TCGA-05-4390	LUAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	0.2778
p.T350S	DO23562	LUAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.2778
p.D357G	TCGA-CM-4748	COAD	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	0.0833
p.D357G	DO10614	COAD	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.0833
p.R338C	TCGA-EE-A2MJ	SKCM	TCGA	IRKQLIPIR	DEG_APCC_DBOX_1	0.2778
p.R338C	DO38099	SKCM	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.2778
p.V356M	DO23192	LINC	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.1111
p.G339R	DO220886	MELA	ICGC	IRKQLIPIR	DEG_APCC_DBOX_1	0.3056
p.I335N	SIDM00313	Hodgkin's Lymphoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	0.1944
p.I335N	ACH-000702	Lymphoma	CCLE	IRKQLIPIR	DEG_APCC_DBOX_1	0.1944
p.I335N	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	IRKQLIPIR	DEG_APCC_DBOX_1	0.1944
p.H349N	SIDM00845	Burkitt's Lymphoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	0.3056
p.H349N	SIDM00035	Thyroid Gland Carcinoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	0.3056
p.H349N	SIDM01519	Head and Neck Carcinoma	GDSC	IRKQLIPIR	DEG_APCC_DBOX_1	0.3056
p.H349N	ACH-000786	Lymphoma	CCLE	IRKQLIPIR	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HDC5	Junctophilin-1	DEG_APCC_DBOX_1	340:348	IRKQLIPIR	APC,CDC20,FZR1	0.5348	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons