DegronMD

Uniprot ID: Q9HDC5

Source protein: Junctophilin-1

Source gene: JPH1

Class: DEG_SCF_FBW7_1

Location: 446:452

E3 ligase: FBXW7

DEGRON score: 0.9815

ASA_SCORE: 90.3143

COIL: 0.9563

CONS_SCORE: 0.3049

DSS_SCORE: 0.7742

HELIX: 0.02

FCONS_SCORE: 1.0152

RIG_SCORE: 0.5373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K441N	TCGA-37-3792	LUSC	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441N	DO27192	LUSC	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.E440K	TCGA-C5-A1MH	CESC	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.1667
p.E440K	DO48982	CESC	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.1667
p.R457C	TCGA-EE-A3JE	SKCM	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.R457C	TCGA-FI-A2D0	UCEC	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.R457C	DO48766	SKCM	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.R457C	DO43891	UCEC	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.R457C	SIDM01588	Endometrial Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.R457C	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPTPKES	DEG_SCF_FBW7_1	0.1944
p.Y456N	TCGA-FW-A3R5	SKCM	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.2222
p.Y456N	DO37406	SKCM	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.2222
p.P449S	TCGA-VQ-A8PP	STAD	TCGA	PPTPKES	DEG_SCF_FBW7_1	0.6752
p.P449S	DO51774	STAD	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.6752
p.T460A	DO225086	BRCA	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.5556
p.H454Y	DO231124	LUSC	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.2778
p.V442I	DO222653	MELA	ICGC	PPTPKES	DEG_SCF_FBW7_1	0.2222
p.K441R	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM00878	Breast Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM01140	Ovarian Carcinoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM00257	Neuroblastoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM00808	Burkitt's Lymphoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.K441R	SIDM01254	Burkitt's Lymphoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.P453H	SIDM01229	Neuroblastoma	GDSC	PPTPKES	DEG_SCF_FBW7_1	0.3056
p.P453H	BE2-M17	autonomic_ganglia	COSMIC	PPTPKES	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HDC5	Junctophilin-1	DEG_SCF_FBW7_1	446:452	PPTPKES	FBXW7	0.9815	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPKES

Degron related mutations and impact score

Drug responses associated with JPH1 mutations

All proteins holding degron of PPTPKES