DegronMD

Uniprot ID: Q9HDC5

Source protein: Junctophilin-1

Source gene: JPH1

Class: DEG_APCC_DBOX_1

Location: 159:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9047

ASA_SCORE: 57.4889

COIL: 0.2558

CONS_SCORE: 0.4034

DSS_SCORE: 0.4207

HELIX: 0.0176

FCONS_SCORE: 1.1196

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G150V	TCGA-56-8307	LUSC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.0833
p.G150V	DO219139	LUSC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.0833
p.R167C	TCGA-AP-A051	UCEC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.719
p.R167C	DO42673	UCEC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.719
p.R160P	TCGA-BA-4076	HNSC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.7512
p.R160P	DO14502	HNSC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.7512
p.T161S	TCGA-DK-A2I4	BLCA	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.7116
p.T161S	DO465	BLCA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.7116
p.G150S	TCGA-DX-A7EU	SARC	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.0833
p.G150S	DO220040	SARC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.0833
p.S162L	TCGA-EE-A2MR	SKCM	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.7667
p.S162L	DO51110	PRAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.7667
p.S162L	DO37819	SKCM	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.7667
p.T153M	TCGA-FJ-A3Z9	BLCA	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.6111
p.T153M	DO44065	BLCA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.6111
p.A152V	TCGA-HU-A4GU	STAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.1389
p.A152V	DO47849	STAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.1389
p.R167H	TCGA-IB-A7LX	PAAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.7133
p.R167H	DO50260	PAAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.7133
p.R156H	TCGA-MX-A5UJ	STAD	TCGA	LRTSLASLR	DEG_APCC_DBOX_1	0.25
p.R156H	DO234155	ESAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.25
p.R156H	DO48547	STAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.25
p.R160H	DO50434	ESAD	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.8244
p.R160H	DO233272	GACA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.8244
p.L163R	DO233884	GACA	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.8428
p.R160C	DO48701	LIRI	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.8301
p.A164T	DO41199	UCEC	ICGC	LRTSLASLR	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HDC5	Junctophilin-1	DEG_APCC_DBOX_1	159:167	LRTSLASLR	APC,CDC20,FZR1	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRTSLASLR

Degron related mutations and impact score

Drug responses associated with JPH1 mutations

All proteins holding degron of LRTSLASLR