DegronMD

Uniprot ID: Q9HDC5

Source protein: Junctophilin-1

Source gene: JPH1

Class: DEG_Kelch_Keap1_1

Location: 540:545

E3 ligase: KEAP1

DEGRON score: 0.9779

ASA_SCORE: 87.2333

COIL: 0.9003

CONS_SCORE: 0.3103

DSS_SCORE: 0.6407

HELIX: 0.056

FCONS_SCORE: 1.0545

RIG_SCORE: 0.549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E545D	TCGA-AA-3715	COAD	TCGA	NPSNGE	DEG_Kelch_Keap1_1	0.6758
p.E545D	DO8018	COAD	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.6758
p.S548F	TCGA-B5-A1MR	UCEC	TCGA	NPSNGE	DEG_Kelch_Keap1_1	0.6944
p.S548F	DO41758	UCEC	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.6944
p.G544R	TCGA-VS-A9UB	CESC	TCGA	NPSNGE	DEG_Kelch_Keap1_1	0.7568
p.G544R	DO219731	CESC	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.7568
p.G544R	SIDM00479	Esophageal Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	0.7568
p.G544R	OE19	oesophagus	COSMIC	NPSNGE	DEG_Kelch_Keap1_1	0.7568
p.R535C	DO223416	CLLE	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.V555M	DO234275	ESAD	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.0556
p.V555A	DO233146	GACA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.0556
p.N543K	DO228986	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.6918
p.R535S	DO229015	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.H537N	DO229037	LICA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.25
p.E545K	DO229462	SKCA	ICGC	NPSNGE	DEG_Kelch_Keap1_1	0.7022
p.R535L	SIDM00721	Small Cell Lung Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.R535L	ACH-002171	Lung Cancer	CCLE	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.R535L	NCI-H250	lung	COSMIC	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.R535H	SIDM01443	Gastric Carcinoma	GDSC	NPSNGE	DEG_Kelch_Keap1_1	0.1944
p.R535H	ACH-000344	Gastric Cancer	CCLE	NPSNGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HDC5	Junctophilin-1	DEG_Kelch_Keap1_1	540:545	NPSNGE	KEAP1	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons