DegronMD

Uniprot ID: Q9H7E2

Source protein: Tudor domain-containing protein 3

Source gene: TDRD3

Class: DEG_APCC_KENBOX_2

Location: 423:427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7516

ASA_SCORE: 87.02

COIL: 0.805

CONS_SCORE: 0.3002

DSS_SCORE: 0.6867

HELIX: 0.151

FCONS_SCORE: 0.9462

RIG_SCORE: 0.6206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R419G	TCGA-33-4566	LUSC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.2222
p.R431T	TCGA-4Z-AA7Y	BLCA	TCGA	AKENP	DEG_APCC_KENBOX_2	0.2222
p.R415Q	TCGA-AX-A0J0	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.R415Q	TCGA-B5-A0JY	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.R415Q	TCGA-BR-4292	STAD	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.R415Q	TCGA-BS-A0UF	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.R415Q	TCGA-F5-6814	READ	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.R428H	TCGA-BS-A0UV	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.3056
p.D417N	TCGA-DF-A2KU	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1667
p.R428C	TCGA-GF-A6C9	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	0.3056
p.P418L	DO15623	HNSC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1944
p.E422V	DO228815	LICA	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3056
p.P429S	DO23604	LUAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.2778
p.Y435H	DO38117	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.G415E	DO219484	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.K416N	ACH-000423	Skin Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.25
p.K416N	SK-MEL-3	skin	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.25
p.P427T	ACH-000633	Gastric Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.5919
p.P427T	FU97	stomach	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.5919
p.G417V	ACH-000888	Lung Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1667
p.G417V	NCI-H1793	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.G416V	NCI-H1793	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.25
p.K415N	SK-MEL-3	skin	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.P426T	FU97	stomach	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_APCC_KENBOX_2	4:8	AKENP	APC,CDC20,FZR1	0.9545	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	1253:1257	AKENP	APC,CDC20,FZR1	0.9045	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_APCC_KENBOX_2	423:427	AKENP	APC,CDC20,FZR1	0.7516	More...
Q9HDC5	Junctophilin-1	DEG_APCC_KENBOX_2	434:438	AKENP	APC,CDC20,FZR1	0.8024	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_APCC_KENBOX_2	181:185	AKENP	APC,CDC20,FZR1	0.9628	More...
Q96SY0	Integrator complex subunit 14	DEG_APCC_KENBOX_2	375:379	AKENP	APC,CDC20,FZR1	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons