DegronMD - Q9H7E2(TDRD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R419G	TCGA-33-4566	LUSC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.2222
p.R431T	TCGA-4Z-AA7Y	BLCA	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.2222
p.R415Q	TCGA-AX-A0J0	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.R415Q	TCGA-B5-A0JY	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.R415Q	TCGA-BR-4292	STAD	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.R415Q	TCGA-BS-A0UF	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.R415Q	TCGA-F5-6814	READ	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.K373I	TCGA-BR-7901	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1111
p.A362T	TCGA-BS-A0UF	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.R428H	TCGA-BS-A0UV	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.3056
p.D417N	TCGA-DF-A2KU	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1667
p.R428C	TCGA-GF-A6C9	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.3056
p.G357D	DO10397	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.P418L	DO15623	HNSC	ICGC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1944
p.E422V	DO228815	LICA	ICGC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.3056
p.P429S	DO23604	LUAD	ICGC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.2778
p.D373G	DO50718	ORCA	ICGC	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1111
p.S367F	DO47613	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.Y435H	DO38117	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.G415E	DO219484	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.S364F	DO47767	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7982
p.K416N	ACH-000423	Skin Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation substituting flanking lysine	0.25
p.K416N	SK-MEL-3	skin	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation substituting flanking lysine	0.25
p.P427T	ACH-000633	Gastric Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation altering degron motif	0.5919
p.P427T	FU97	stomach	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation altering degron motif	0.5919
p.G417V	ACH-000888	Lung Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1667
p.G417V	NCI-H1793	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1667
p.G416V	NCI-H1793	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation substituting flanking lysine	0.25
p.K415N	SK-MEL-3	skin	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation rewiring degron network	0.1111
p.P426T	FU97	stomach	COSMIC	AKENP	DEG_APCC_KENBOX_2	423:427	Mutation altering degron motif	0.7031

Kaplan plot for TDRD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDRD3

UniProt ID: Q9H7E2

Entrez ID: 81550

Protein name: Tudor domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TDRD3 in