DegronMD

Uniprot ID: Q96SY0

Source protein: Integrator complex subunit 14

Source gene: INTS14

Class: DEG_APCC_KENBOX_2

Location: 375:379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7404

ASA_SCORE: 84.5

COIL: 0.8884

CONS_SCORE: 0.4467

DSS_SCORE: 0.6575

HELIX: 0.0826

FCONS_SCORE: 0.7748

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R384Q	SIDM01047	Chronic Myelogenous Leukemia	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1944
p.L388V	SIDM00363	Acute Myeloid Leukemia	GDSC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.L388V	SIDM01682	Gastric Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.L388V	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.L366V	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.D377V	PEO1	ovary	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_APCC_KENBOX_2	4:8	AKENP	APC,CDC20,FZR1	0.9545	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	1253:1257	AKENP	APC,CDC20,FZR1	0.9045	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_APCC_KENBOX_2	423:427	AKENP	APC,CDC20,FZR1	0.7516	More...
Q9HDC5	Junctophilin-1	DEG_APCC_KENBOX_2	434:438	AKENP	APC,CDC20,FZR1	0.8024	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_APCC_KENBOX_2	181:185	AKENP	APC,CDC20,FZR1	0.9628	More...
Q96SY0	Integrator complex subunit 14	DEG_APCC_KENBOX_2	375:379	AKENP	APC,CDC20,FZR1	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons