DegronMD

Uniprot ID: Q8TEW0

Source protein: Partitioning defective 3 homolog

Source gene: PARD3

Class: DEG_SCF_FBW7_1

Location: 576:583

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 70.55

COIL: 0.838

CONS_SCORE: 0.529

DSS_SCORE: 0.5339

HELIX: 0.0451

FCONS_SCORE: 1.0632

RIG_SCORE: 0.7775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D573Y	TCGA-AZ-4315	COAD	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	0.25
p.D573Y	DO8842	COAD	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	0.25
p.D581N	TCGA-D8-A1XJ	BRCA	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	0.5821
p.D581N	DO5611	BRCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	0.5821
p.E585K	TCGA-E7-A541	BLCA	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	0.2778
p.E585K	DO44037	BLCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	0.2778
p.E590D	DO227802	COCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	0.1389
p.P566L	SIDM00445	Esophageal Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	0.0556
p.P566L	ACH-002292	Esophageal Cancer	CCLE	IVLTPDGT	DEG_SCF_FBW7_1	0.0556
p.P566L	OACp4C	oesophagus	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	0.0556
p.D575N	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	0.3056
p.D575N	SIDM01582	Gastric Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	0.3056
p.A573T	SNU-1040	large_intestine	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	0.25
p.P587S	SNU-C5	large_intestine	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEW0	Partitioning defective 3 homolog	DEG_SCF_FBW7_1	576:583	IVLTPDGT	FBXW7	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons