DegronMD

Uniprot ID: Q8TEW0

Source protein: Partitioning defective 3 homolog

Source gene: PARD3

Class: DEG_SPOP_SBC_1

Location: 442:446

E3 ligase: SPOP

DEGRON score: 0.5367

ASA_SCORE: 85.44

COIL: 0.8632

CONS_SCORE: 0.2554

DSS_SCORE: 0.5164

HELIX: 0.0376

FCONS_SCORE: 0.6097

RIG_SCORE: 0.71

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y451H	TCGA-CM-5861	COAD	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1944
p.Y451H	DO7918	COAD	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1944
p.S433Y	TCGA-UY-A8OB	BLCA	TCGA	VFSTT	DEG_SPOP_SBC_1	0.0833
p.S433Y	DO219037	BLCA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.0833
p.Y451C	TCGA-ZP-A9D2	LIHC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1944
p.Y451C	DO52333	LIHC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1944
p.T446N	DO229045	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.7055
p.T453N	DO229224	THCA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1389
p.N452D	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1667
p.A454V	TE-9	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2702:2706	VFSTT	SPOP	0.9768	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	5:9	VFSTT	SPOP	0.9925	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_SPOP_SBC_1	442:446	VFSTT	SPOP	0.5367	More...
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_SPOP_SBC_1	1059:1063	VFSTT	SPOP	0.8676	More...
Q9P2E2	Kinesin-like protein KIF17	DEG_SPOP_SBC_1	500:504	VFSTT	SPOP	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons