DegronMD

Uniprot ID: Q9P2E2

Source protein: Kinesin-like protein KIF17

Source gene: KIF17

Class: DEG_SPOP_SBC_1

Location: 500:504

E3 ligase: SPOP

DEGRON score: 0.8533

ASA_SCORE: 82.62

COIL: 0.7128

CONS_SCORE: 0.2105

DSS_SCORE: 0.3802

HELIX: 0.1926

FCONS_SCORE: 1.016

RIG_SCORE: 0.7603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D511N	TCGA-06-5416	GBM	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D511N	TCGA-3B-A9HT	SARC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D511N	TCGA-FI-A2D5	UCEC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D511N	DO10880	GBM	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D511N	DO219934	SARC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D511N	DO41331	UCEC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1389
p.S513F	TCGA-44-2659	LUAD	TCGA	VFSTT	DEG_SPOP_SBC_1	0.0833
p.S513F	DO23744	LUAD	ICGC	VFSTT	DEG_SPOP_SBC_1	0.0833
p.V495E	TCGA-44-5644	LUAD	TCGA	VFSTT	DEG_SPOP_SBC_1	0.1944
p.V495E	DO25153	LUAD	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1944
p.T503M	DO233772	GACA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.7423
p.K499N	DO232224	PBCA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2702:2706	VFSTT	SPOP	0.9768	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	5:9	VFSTT	SPOP	0.9925	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_SPOP_SBC_1	442:446	VFSTT	SPOP	0.5367	More...
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_SPOP_SBC_1	1059:1063	VFSTT	SPOP	0.8676	More...
Q9P2E2	Kinesin-like protein KIF17	DEG_SPOP_SBC_1	500:504	VFSTT	SPOP	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons