DegronMD - Q8WWL7(CCNB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G393R	TCGA-21-1082	LUSC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.3056
p.G393R	DO26463	LUSC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.3056
p.R397P	TCGA-33-4538	LUSC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.6401
p.R397P	DO26695	LUSC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.6401
p.T1055N	TCGA-44-A479	LUAD	TCGA	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2222
p.T1055N	DO23633	LUAD	ICGC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2222
p.L1049F	TCGA-66-2785	LUSC	TCGA	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0556
p.L1049F	DO26520	LUSC	ICGC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0556
p.E405D	TCGA-AG-A002	READ	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.25
p.S412L	TCGA-AP-A0LM	UCEC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.0556
p.S412L	DO43306	UCEC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.0556
p.R397H	TCGA-D1-A174	UCEC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.7133
p.R397H	TCGA-VS-A9UJ	CESC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.7133
p.R397H	DO219735	CESC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.7133
p.R397H	DO228577	LICA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.7133
p.R397H	DO40900	UCEC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.7133
p.L398V	TCGA-DG-A2KM	CESC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.6765
p.L398V	DO51597	CESC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.6765
p.G409E	TCGA-EB-A5FP	SKCM	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1389
p.G409E	DO47362	SKCM	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1389
p.P1057T	TCGA-EU-5905	KIRC	TCGA	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2778
p.P1057T	DO18622	KIRC	ICGC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2778
p.E1065D	DO228474	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2778
p.K386N	DO229015	LICA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation substituting flanking lysine	0.2222
p.IP1050IA	DO222749	MELA	ICGC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0
p.P400T	DO35148	PACA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.5919
p.S1056N	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.25
p.S1056N	ACH-000840	Lung Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.25
p.S1056N	HCC-366	lung	COSMIC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.25
p.V402L	SIDM00683	Prostate Carcinoma	GDSC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.5654
p.V402L	ACH-000977	lymph node	CCLE	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.5654
p.S1071F	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.S1071F	ACH-002216	Leukemia	CCLE	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.S1071F	BE-13	haematopoietic and lymphoid tissue	COSMIC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.R397C	SIDM00293	Small Cell Lung Carcinoma	GDSC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.719
p.R397C	ACH-002052	Lung Cancer	CCLE	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.719
p.R397C	LU-139	lung	COSMIC	KRSRLKPLV	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.719
p.E1069D	SIDM00534	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1667
p.E1069D	ACH-000986	Colon/Colorectal Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1667
p.E1069D	HT-115	large intestine	COSMIC	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1667
p.S1071Y	ACH-000109	Lung Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111

Kaplan plot for CCNB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNB3

UniProt ID: Q8WWL7

Entrez ID: 85417

Protein name: G2/mitotic-specific cyclin-B3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNB3 in